DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and mct-6

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_510705.1	Gene:	mct-6 / 181724	WormBaseID:	WBGene00015676	Length:	594	Species:	Caenorhabditis elegans

Alignment Length:	794	Identity:	199/794 - (25%)
Similarity:	307/794 - (38%)	Gaps:	232/794 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SSSTEKKTPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLFFS 186
            ||...|..|..||||:|||||..|..|.:.|||..:|||::...|:|.|..|.:..|.|.||...
Worm     7 SSGGGKLVPLPPDGGWGWVVVLGSFFVHVFADGFVYSFGVLVETLMEEFHASNTMAALIISLLTG 71

  Fly   187 VPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAV 251
            :.|..||:.|.:.:|||||..||.|..|:..|.|||.|..::..:::|.|:|.|.|.|:.|..|:
Worm    72 LTLGSGPLASAVCNKYGCRITTITGAGVAFVGCALSYFATAMWHIVITVGVIMGTGFGLMYCPAI 136

  Fly   252 VSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRD 316
            |.:..:|:.||:.||||..:|.|:||.::|.:.::.|.:||||...|.....::...:|||....
Worm   137 VIVTMYFENKRSLATGIAVAGAGVGTVLFAPINAFFINNYGWRSVFLAFLFILVLCALCGATFAP 201

  Fly   317 PDWLI---EENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDP 378
            .::.:   ||..:           |..|..|::||                    |.||::
Worm   202 LEFALVPDEEEEV-----------NDEVLDEDVKK--------------------TAANEE---- 231

  Fly   379 LDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEA-----PS-RENLLSMSSGAG 437
                                                    .||:|     || .|..:|.|||
Worm   232 ----------------------------------------HGEKATLLSPPSLLERSMSQSSG-- 254

  Fly   438 AYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQ 502
                                ..:|.|:.:.|     .::...:..|..|:..|::...|.|||.:
Worm   255 --------------------VQKAGEKIRPA-----SSMGAVDVESQPRSRRGTVGERDSGYLNR 294

  Fly   503 KHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPT 567
            |          ::|.    |.||||          |....||...|.|.......       ..|
Worm   295 K----------DVFY----TGSISN----------VAEFREDPDKYRSTGSLHGR-------HTT 328

  Fly   568 VIAIPEQEQSVNSELATRRARLDSI-TGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRN 631
            |.:||          |....|||.: .|....|::...|...:......::...|..|
Worm   329 VGSIP----------AHSTGRLDDVREGSEEDSKAMDISEKTNGTDNTDNVEGKNMFK------- 376

  Fly   632 SIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALF 696
                                                          |:.::....|.|:..|.||
Worm   377 ----------------------------------------------TISNMLSLELLLEPTFLLF 395

  Fly   697 NLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLS-------- 753
            .:|.|...:.|..|..:||.:..:...:..|.::::|..|::.|||.|..|.:.|..
Worm   396 AISNLLTSVGFNSPLYFLPLHATKIGLEPIQGSKVLSAFGVSNTVGRIIFGVVADHKLPLPGGIG 460

  Fly   754 --------WMNINICYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSI 810
                    ||     |::.:.:||....|. .....::.|.....:|||:.||....|..|||.:
Worm   461 NDTARNRLWM-----YNISLTICGLLTVFC-YQFNGFIPLATYSALFGFSIASYICLTSVILVDL 519

  Fly   811 VDLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCEKK 875
            :.||..|.|:||:||.||||.:.|||::|.:.:.||.:..:|.:.|:.:..||:..:.|.|.:||
Worm   520 LGLDKLTNAFGLLLLWQGVGTVFGPPVSGYLADMTGNYTLSFVFCGVNLLASGLMLFGIPFFQKK 584

  Fly   876 APKESDSDVLETKK 889
            |..::    |..||
Worm   585 AKAKA----LAIKK 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	64/171 (37%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	58/199 (29%)
mct-6	NP_510705.1	MFS_MCT_SLC16	23..579	CDD:340910	183/757 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910