DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and SLC16A14

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_689740.2	Gene:	SLC16A14 / 151473	HGNCID:	26417	Length:	510	Species:	Homo sapiens

Alignment Length:	763	Identity:	176/763 - (23%)
Similarity:	279/763 - (36%)	Gaps:	285/763 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 GDSIDSSSTEKKTPKMP----DGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKT 177
            |...:....:|||.| |    |||:.|::|.:|..|.::..|...:.|::|||.||.|.:|...|
Human     9 GYDFEDGPKDKKTLK-PHPNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLT 72

  Fly   178 AWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLG 242
            ||:|||...:.|::||.....::..|||:..|:||:|::.|:.||::..::..|.:|||:.:|||
Human    73 AWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLG 137

  Fly   243 LGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNA 307
            .|:.|:.|||.:..:|.|:|..|.|:..:|||.|||:...|..||...||||.|.||.|...||.
Human   138 SGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNL 202

  Fly   308 CVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEAN 372
            ||||||||
Human   203 CVCGALMR--------------------------------------------------------- 210

  Fly   373 QQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAG 437
                 ||                                           :|.:
Human   211 -----PL-------------------------------------------SPGK----------- 216

  Fly   438 AYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQ 502
                      :|:|                          |.||...|
Human   217 ----------NPND--------------------------PGEKDVRG----------------- 228

  Fly   503 KHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPT 567
                          :..|:|.|:.:....|        .:|:.......:||...|:...
Human   229 --------------LPAHSTESVKSTGQQG--------RTEEKDGGLGNEETLCDLQAQE----- 266

  Fly   568 VIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNS 632
               .|:|                              :.||.|:.....::..::|
Human   267 ---CPDQ------------------------------AGHRKNMCALRILKTVSWL--------- 289

  Fly   633 IHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFN 697
                     |.|.|                  |..|| ||..:..|.      |||.:..|..|.
Human   290 ---------TMRVR------------------KGFED-WYSGYFGTA------SLFTNRMFVAFI 320

  Fly   698 LSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAE---LISDVGIAQTVGMIGLGYLGDLSWMNINI 759
            ...||.:..|:||:::||:.:.  .|::|:..:   |.|.:.|....|.:.||.:.||..:::..
Human   321 FWALFAYSSFVIPFIHLPEIVN--LYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCISVWN 383

  Fly   760 CYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVL 824
            .:.|.......|:|.:||:.| |.||.|:|.:.||: :..||..|.:...:|.::....|||:::
Human   384 VFLLANFTLVLSIFILPLMHT-YAGLAVICALIGFS-SGYFSLMPVVTEDLVGIEHLANAYGIII 446

  Fly   825 LVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFC 872
            ...|:..:.|||.||.||:.|.::|.:||..|: :.:.|:...||:.|
Human   447 CANGISALLGPPFAGWIYDITQKYDFSFYICGL-LYMIGILFLLIQPC 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	72/171 (42%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	56/186 (30%)
SLC16A14	NP_689740.2	2A0111	24..490	CDD:331689	168/742 (23%)
SLC16A14	NP_689740.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..255		12/126 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.919607	Normalized mean entropy	S5541
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8605
orthoMCL	1	0.900	-	-		OOG6_109654
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4139
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690