Protein Alignment chk and Mct1

DIOPT Version :10

• Sequence 1: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_311120.3
• Gene: Mct1 / 1272237
• VectorBaseID: AGAMI1_011930
• Length: 606
• Species: Anopheles gambiae
• Alignment Length: 772
• Identity: 206/772 - (26%)
• Similarity: 321/772 - (41%)
• Gaps: 206/772 - (26%)

  Fly   106 KRRKRLISNESGDSIDSSSTE---KKTPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELL 167
            ||:::.|.::    |:.|.||   ...|..||||:||:||.||..:.:|.|||::|||:...|.|
Mosquito    10 KRQQQQIDSD----IEQSVTEVDPNGLPTPPDGGWGWMVVLASFSIHIITDGLTYSFGIFYSEFL 70

  Fly   168 EYFGESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLM 232
            .||.|....||||:|:...|.|..|||.|:||::||||.:||.|.::::...|:|.:..|:.||.
Mosquito    71 TYFNEGKGYTAWIASILVGVTLCSGPISSSLVNRYGCRAVTIAGALLASASLAVSMYATSVFMLF 135

  Fly   233 VTFGIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGAT 297
            :|.|:.:|||||:.|:.|:||:..:|::.|:.||||...|:|:||.::|.||..||:.:.|:||.
Mosquito   136 ITIGVGTGLGLGLIYLPAIVSVTMYFERLRSLATGIAVCGSGLGTSIFAPLTEALIKKFQWQGAL 200

  Fly   298 LILGGTMLNACVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDS 362
            |.:.|.:| .||...||..|  |:.|.....:.            |:|        :.:.:..|.
Mosquito   201 LAIAGIVL-ICVLFGLMFRP--LVHEPASPGKE------------LQE--------LPQHSSADP 242

  Fly   363 LVTKNNTEANQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSL----RHKEGEEA 423
            ..|...|..|..     :|.|||..|.    ..:...::|......|.|..:|    |...||:|
Mosquito   243 STTMKPTSGNAN-----ESNLKRSNSH----GHVDAPKIDLNANGHSASGHNLDKHTRTTPGEDA 298

  Fly   424 PSRENLLSMSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTP 488
                ..|.:|                                 :..|.:.|::.|...:   ||.
Mosquito   299 ----KRLGLS---------------------------------QPLLTAPESVQPVPLK---RTE 323

  Fly   489 NGSLRSSDEGYLTQKH-ASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKD 552
            :|::...|..|....| .:||::...|:.:  :...|..:::.|||.
Mosquito   324 SGTMYRKDALYTGSVHNIASRHASQANLSI--YEKGSYGSVQGNGLH------------------ 368

  Fly   553 ETFALLEPSRRIRPTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISI 617
                        ||.  |.|:..:
Mosquito   369 ------------RPP--AEPDAPE----------------------------------------- 378

  Fly   618 RNSNFLKDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSI 682
                                          |...|....|.:                .||.:.:
Mosquito   379 ------------------------------RCLGCIPCSRET----------------CDTFREM 397

  Fly   683 FDFSLFLDMKFALFNLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLG 747
            .:||:..|..|.:|.:|.....:.|.:||:||....:........::.|:..:|||.|||.|.||
Mosquito   398 MNFSILKDPIFIIFTVSNFLTSVGFNVPYVYLAAQAQVLGIGSKDASYLLGIIGIANTVGRIVLG 462

  Fly   748 YLGDLSWMNINICYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVD 812
            ||.|..|:|....|:..:.|||.:. .:.:|..::..|.|...::|||..:....|..|||.::.
Mosquito   463 YLSDKPWVNRLAVYNCSLAVCGIAT-ALSVLCVDFYWLGVYSAVYGFTIGAYVGLTSVILVDLLG 526

  Fly   813 LDDFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLI 869
            |:..|.|:||:||.||:....||||||.:|:||..:...|..||..||:||...:.|
Mosquito   527 LEKLTNAFGLLLLFQGIASFVGPPIAGWLYDYTLSYGPGFIMAGTTIAISGAMLFAI 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	78/176 (44%)
		MFS	<687..869	CDD:475125	63/181 (35%)
Mct1	XP_311120.3	MFS_MCT_SLC16	41..584	CDD:340910	194/737 (26%)