DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and Slc16a6

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001025013.1	Gene:	Slc16a6 / 104681	MGIID:	2144585	Length:	607	Species:	Mus musculus

Alignment Length:	793	Identity:	154/793 - (19%)
Similarity:	272/793 - (34%)	Gaps:	312/793 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 ESGDSIDSSSTEKKT---------PKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYF 170
            |:|.| .|..|:|.:         .::||||:||.|..:...|.:...|:..|||:...:|::.|
Mouse    77 ETGCS-RSRMTQKNSKLCARANVYTQVPDGGWGWAVAVSFFFVEVFTYGIIKSFGVFFNDLMDSF 140

  Fly   171 GESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTF 235
            .||.||.:||.|:...|.....|:.:.|.:::|.|.:.:.||::.:.|...:||...:..:.::.
Mouse   141 DESNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFSQRVYHMYISI 205

  Fly   236 GIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLIL 300
            |:|||||....::..|..::.:|||:|:..|.:.::|.....|.:|...:.|.|..|||.:.|.:
Mouse   206 GVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFV 270

  Fly   301 GGTMLNACVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLE---EIKKLLDTGITKEAVLDS 362
            |...||..|||||:|.   :|    ::...|     |..:|.||   |::.:|:...|:.::
Mouse   271 GLLQLNIMVCGALLRP---II----IQGPGQ-----SPKAVTLEPRREVQYMLENEKTRTSI--- 320

  Fly   363 LVTKNNTEANQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRE 427
                          |.:||.::           |:|
Mouse   321 --------------DSIDSGVE-----------LTT----------------------------- 331

  Fly   428 NLLSMSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSL 492
                                ||.:.                         |||.:
Mouse   332 --------------------SPKNV-------------------------PSEAK---------- 341

  Fly   493 RSSDEGYLTQKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFAL 557
                                                                     .:.||.|
Mouse   342 ---------------------------------------------------------MEQETRA- 348

  Fly   558 LEPSRRIRPTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNF 622
                           ||:|::             :|.         |.|.:
Mouse   349 ---------------EQQQTL-------------VTA---------PKHSQ-------------- 362

  Fly   623 LKDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKS-IFDFS 686
                                                                    ||: :.|||
Mouse   363 --------------------------------------------------------MKAPLLDFS 371

  Fly   687 LFLDMKFALFNLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGD 751
            :..:..|..:.|..||..:.|..|.||:.........|..::|.|:|.:.||:..|.||.|::
Mouse   372 VLKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDPDRAAFLLSTMAIAEVFGRIGAGFV-- 434

  Fly   752 LSWMNINICY--SLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVS---IV 811
            |:...|...|  .:|:::..||:|.. ...|.:.|||:..|.|| :...:...|...:::   :|
Mouse   435 LNREPIRKIYIELICVILLTASLFAF-TFATEFWGLMLCSVFFG-SMVGTIGGTHIPMLAEDDVV 497

  Fly   812 DLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCEKKA 876
            .::..:.|.|:.:.:|.:..:||||:||::.:.:..:...||.....:.|:.||..|:..|:|..
Mouse   498 GIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVRPCKKGL 562

  Fly   877 PKESDSDVLETKK 889
            .:.|.|...:|.:
Mouse   563 CQNSHSGENQTDR 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	53/171 (31%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	50/188 (27%)
Slc16a6	NP_001025013.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84		3/7 (43%)
		2A0113	101..592	CDD:273325	148/768 (19%)
		MFS	109..556	CDD:119392	138/739 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8713
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910