Protein Alignment chk and slc16a1a

DIOPT Version :10

• Sequence 1: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001243569.1
• Gene: slc16a1a / 100534752
• ZFINID: ZDB-GENE-110408-16
• Length: 461
• Species: Danio rerio
• Alignment Length: 773
• Identity: 140/773 - (18%)
• Similarity: 228/773 - (29%)
• Gaps: 360/773 - (46%)

  Fly   129 TPKMPDGGYGWVVVFASLVVSLIADGLSFSF-GLINV---ELLEYFGESTSKTAWISSLFFSVPL 189
            ||  |:||:||.||..    :.|:.|.|::| ..|.|   |:...|..::|:.:||||:..:|..
Zfish    12 TP--PEGGWGWAVVLG----AFISIGFSYAFPKSITVFFKEIEVIFNATSSQVSWISSIMLAVMY 70

  Fly   190 LMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSI 254
            ..||:.|.||:|||.|.:.||||.:|..|...:||||::|.|....|::.||||......|:..|
Zfish    71 GGGPVSSILVNKYGSRPIMILGGCLSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMI 135

  Fly   255 AFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDW 319
            ..:|.|||..|.||..:|:.:.....|.|.::..:.:||||:.|||||.:||.||.|:|||
Zfish   136 GKYFYKKRPIANGIAMAGSPVFLSTLAPLNTWFFDQFGWRGSFLILGGLLLNCCVAGSLMR---- 196

  Fly   320 LIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALK 384
                                                                             
Zfish   197 ----------------------------------------------------------------- 196

  Fly   385 RYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSP 449
                                                                             
Zfish   197 ----------------------------------------------------------------- 196

  Fly   450 DDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNEN 514
                                                  |.|
Zfish   197 --------------------------------------PIG------------------------ 199

  Fly   515 IFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVN 579
                                                                     |:.:.:|.
Zfish   200 ---------------------------------------------------------PKPQPAVK 207

  Fly   580 SELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHR 644
            ::                                     |||
Zfish   208 AD-------------------------------------NSN----------------------- 212

  Fly   645 YRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWFII 709
                             :.|||.:     ..|:.:....|.:||....|.|:.|..:.:|.....
Zfish   213 -----------------SRAKERK-----TVVEVINGFIDLTLFKHRGFLLYLLGNVVMFFGLFS 255

  Fly   710 PYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWM--NINICYSLCMLVCGASV 772
            |.::|.:|.|..:....::|.|:|.:.....|....:|.:.:..|:  .:...::..:|:.|...
Zfish   256 PLVFLSNYAKSKQIPREKAAFLLSILAFVDMVARPSMGIVANTKWVRPRVQHFFAASILLNGVCH 320

  Fly   773 FFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPI 837
            ...| |.|:|.|.::..:.|||.|....|.....|:.:|....|:.|.|||.:|:...::.|||:
Zfish   321 LLAP-LSTDYTGFVIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECGPVLLGPPL 384

  Fly   838 AGVIYEYTGRWDDTFYYAGIFIALSGVCSYL-----IEFCEKKAPKESDSDVLETKKA 890
            .|...:....:..|:...||.:.:..:..::     .:..|::|.:||       |||
Zfish   385 LGKFNDIYHDYKYTYMGCGIVLLIGSLFLFVGMGINYKLLEREAKEES-------KKA 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	71/180 (39%)
		MFS	<687..869	CDD:475125	43/188 (23%)
slc16a1a	NP_001243569.1	MFS_MCT1	19..417	CDD:340984	128/737 (17%)