Protein Alignment chk and slc16a5

DIOPT Version :10

• Sequence 1: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_002940018.3
• Gene: slc16a5 / 100485544
• XenbaseID: XB-GENE-1008043
• Length: 455
• Species: Xenopus tropicalis
• Alignment Length: 765
• Identity: 134/765 - (17%)
• Similarity: 232/765 - (30%)
• Gaps: 365/765 - (47%)

  Fly   133 PDGGYGWVVVFASLVVSLIADGLSFSF----GLINVELLEYFGESTSKTAWISSLFFSVPLLMGP 193
            |||.:.|||    |...::..|||..|    |:...::...|..|.::|:|..|:..:|....||
 Frog     4 PDGPWAWVV----LAAVMLTQGLSLGFPSCIGIFYTDIQTSFQASNTETSWFPSIIMAVLHAGGP 64

  Fly   194 IWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWF 258
            :.:.:|:::|||...::||::...|...|:|..:|..|.::.|.:.|||....:...:..:.::|
 Frog    65 LCTIMVERFGCRVTVMVGGLLCGVGMVTSAFSQTIIHLYLSAGFVGGLGFCFCFQAGITVLGYYF 129

  Fly   259 DKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLIEE 323
            .::||.|..:.::|..||..::...:.:|:|:.||||:.|:.||.:||.|||||:||
 Frog   130 IRRRTLANSLASAGASIGMALWPLASQHLLETMGWRGSFLLFGGVLLNCCVCGAIMR-------- 186

  Fly   324 NRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYRS 388
                                                                             
 Frog   187 ----------------------------------------------------------------- 186

  Fly   389 EIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTL 453
                             .|:||..
 Frog   187 -----------------PVRSLEP----------------------------------------- 193

  Fly   454 MGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFMA 518
                |||.            |.|:|.|.
 Frog   194 ----AHEK------------EVLAPEEP------------------------------------- 205

  Fly   519 KHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSELA 583
                        ||::|..              ::|                  ||.:.:...:|
 Frog   206 ------------NGIKHKG--------------EKT------------------EQGKGLQRYMA 226

  Fly   584 TRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLR 648
                                                                             
 Frog   227 ----------------------------------------------------------------- 226

  Fly   649 ASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYLY 713
                                              ||. ||...::.::.|...::.:.|::|..|
 Frog   227 ----------------------------------FDL-LFRHRRYQIYALGVTWMVLGFVLPLFY 256

  Fly   714 LPDYMKQYKYDVSQSAELISDVG-----IAQTVGMIG--------LGYLGDLSWMNINICYSLCM 765
            |..|......|..::|.|:|.||     :....|::.        |.||..::    .|...|..
 Frog   257 LVPYATSNDIDEKKAALLLSLVGFMNIFMRPMAGLVSQQKVFHGRLMYLFSVA----VILNGLSN 317

  Fly   766 LVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVG 830
            |||...|.| |.|:|       .||::..|.:...|....:|:..|.:..|..|:||..:::.:.
 Frog   318 LVCAIWVSF-PALLT-------YCVLYSITMSFIGSLIFQVLMDTVGMKRFPGAFGLFTILESIT 374

  Fly   831 MIAGPPIAGVIYEYTGRWDDTFYYAGIFIALS----GVCSYLIEFCEKKA 876
            ::||||:||::.:.||::...||.:.|.:..|    |:.|:.::..|.||
 Frog   375 IMAGPPLAGLLVDITGQYGLVFYASSIAVTSSGLFMGLASFAVDRSEAKA 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	55/180 (31%)
		MFS	<687..869	CDD:475125	52/198 (26%)
slc16a5	XP_002940018.3	MFS_MCT6	9..414	CDD:340983	127/748 (17%)