Protein Alignment Rab2 and RAB5A

DIOPT Version :10

• Sequence 1: NP_477090.1
• Gene: Rab2 / 35577
• FlyBaseID: FBgn0014009
• Length: 213
• Species: Drosophila melanogaster
• Sequence 2: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Alignment Length: 218
• Identity: 77/218 - (35%)
• Similarity: 120/218 - (55%)
• Gaps: 36/218 - (16%)

  Fly     7 FKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQEAFRSI 71
            ||.:::|::.||||.|:|:|...:|....:.|||..|..:.:.:|...:|.:||||||||.:.|:
Human    21 FKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSL 85

  Fly    72 TRSYYRGAAGALLVYDITRRETFNHLTTWLEDARQHSNSNMVIMLIGNKSDLDSRREVKKEEGEA 136
            ...|||||..|::|||||..|:|.....|:::.::.::.|:||.|.|||:||.::|.|..:|.::
Human    86 APMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQS 150

  Fly   137 FAREHGLVFMETSARTAANVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGQQHSPTN-PSLPG 200
            :|.::.|:||||||:|:.||.|.|:..||::                         |.| |..||
Human   151 YADDNSLLFMETSAKTSMNVNEIFMAIAKKL-------------------------PKNEPQNPG 190

  Fly   201 AGGAAG----------AANSGCC 213
            |..|.|          ...:.||
Human   191 ANSARGRGVDLTEPTQPTRNQCC 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab2	NP_477090.1	PLN03108	1..213	CDD:178655	75/216 (35%)
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	67/185 (36%)
		Switch 1. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	44..56		4/11 (36%)
		Switch 2. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	77..93		8/15 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		10/58 (17%)