Protein Alignment Rab2 and RAB1A

DIOPT Version :10

• Sequence 1: NP_477090.1
• Gene: Rab2 / 35577
• FlyBaseID: FBgn0014009
• Length: 213
• Species: Drosophila melanogaster
• Sequence 2: NP_004152.1
• Gene: RAB1A / 5861
• HGNCID: 9758
• Length: 205
• Species: Homo sapiens
• Alignment Length: 211
• Identity: 97/211 - (45%)
• Similarity: 138/211 - (65%)
• Gaps: 13/211 - (6%)

  Fly     3 YAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQEA 67
            |.||||.::|||:|||||||||:|.|..:...:..||||:|..|.|.:|||.||||||||||||.
Human     8 YDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQER 72

  Fly    68 FRSITRSYYRGAAGALLVYDITRRETFNHLTTWLEDARQHSNSNMVIMLIGNKSDLDSRREVKKE 132
            ||:||.||||||.|.::|||:|.:|:||::..||::..::::.|:..:|:|||.||.:::.|...
Human    73 FRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYT 137

  Fly   133 EGEAFAREHGLVFMETSARTAANVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGQQHSPTNPS 197
            ..:.||...|:.|:||||:.|.|||::|:..|.||.:::..|......|.:.:||  |.:|...|
Human   138 TAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKI--QSTPVKQS 200

  Fly   198 LPGAGGAAGAANSGCC 213
                ||       |||
Human   201 ----GG-------GCC 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab2	NP_477090.1	PLN03108	1..213	CDD:178655	95/209 (45%)
RAB1A	NP_004152.1	Rab1_Ypt1	10..175	CDD:206661	84/164 (51%)
		Switch 1. /evidence=ECO:0000269|PubMed:22416225, ECO:0007744|PDB:3SFV, ECO:0007744|PDB:3TKL	34..48		4/13 (31%)
		Switch 2. /evidence=ECO:0000269|PubMed:22416225, ECO:0007744|PDB:3SFV, ECO:0007744|PDB:3TKL	66..83		13/16 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	178..205		10/39 (26%)