DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc1 and AAS

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_849999.1	Gene:	AAS / 816553	AraportID:	AT2G20340	Length:	490	Species:	Arabidopsis thaliana

Alignment Length:	486	Identity:	211/486 - (43%)
Similarity:	292/486 - (60%)	Gaps:	29/486 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVEEFRKYGKEVIDYICQYGTNIEERDVAPTLDPGYLKKLLPADAPQSPEPFKDVLEDFEQKIM 65
            ||.|:.|:||..::|:|..|...||:..|...:.||||.||||..||..||....||:|...||:
plant    12 MDSEQLREYGHLMVDFIADYYKTIEDFPVLSQVQPGYLHKLLPDSAPDHPETLDQVLDDVRAKIL 76

  Fly    66 PGVVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPK 130
            |||.||..|.||||:||.:|....||:|||:.:|.:||||.:.|||.|||.||::|.||.|.||:
plant    77 PGVTHWQSPSFFAYYPSNSSVAGFLGEMLSAGLGIVGFSWVTSPAATELEMIVLDWVAKLLNLPE 141

  Fly   131 AFVSDAPGSTGGGALQGSASECVLVSLITARARAISELKGQTSVHDSVFLPSLIAYASREAHSSV 195
            .|:|.   ..|||.:||||||.|||.||.||.:.:..: |:.:      |..|:.|:|.:.||::
plant   142 QFMSK---GNGGGVIQGSASEAVLVVLIAARDKVLRSV-GKNA------LEKLVVYSSDQTHSAL 196

  Fly   196 EKATKMALV---KLRII--DADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDIT 255
            :||.::|.:   ..|::  |:..:..:|.:.|::|:..|:.|||.|||:.|.||||...|.|.:.
plant   197 QKACQIAGIHPENCRVLTTDSSTNYALRPESLQEAVSRDLEAGLIPFFLCANVGTTSSTAVDPLA 261

  Fly   256 EIGKVCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALWVRDV 320
            .:||:... :.||.|||.||||::.|.||.|.:..|:|.|||||.|.:|..|||||.|.|||:|.
plant   262 ALGKIANS-NGIWFHVDAAYAGSACICPEYRQYIDGVETADSFNMNAHKWFLTNFDCSLLWVKDQ 325

  Fly   321 MNLKSALNVNPLYLRHEHLTG---VDYRHYGIPLSRRFRALKLWFVFRTYGIRGLQEYIRNHMAL 382
            .:|..||:.||.:|:::....   |||:.:.|||.||||:||||.|.|.||...|:.|||||:.|
plant   326 DSLTLALSTNPEFLKNKASQANLVVDYKDWQIPLGRRFRSLKLWMVLRLYGSETLKSYIRNHIKL 390

  Fly   383 AKKFEMLVRKDERFEVRNDVHLGLVCFRM-------RTGDEPNHMLLAQINHSGKMHMTPAKFNG 440
            ||:||.||.:|..||:.......|||||:       :..:..|..||..:|.|||:.|:....:|
plant   391 AKEFEQLVSQDPNFEIVTPRIFALVCFRLVPVKDEEKKCNNRNRELLDAVNSSGKLFMSHTALSG 455

  Fly   441 RYVIRFCVTYEHATEKDILEAWTQIKCFAEE 471
            :.|:|..:......||.:.|||   |...||
plant   456 KIVLRCAIGAPLTEEKHVKEAW---KIIQEE 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	180/391 (46%)
AAS	NP_849999.1	PLN02880	3..490	CDD:215475	211/486 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	368	1.000	Domainoid score	I180
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	417	1.000	Inparanoid score	I444
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D856958at2759
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		mtm1068
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	O	PTHR11999
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840