DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc1 and csad

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_009295318.1	Gene:	csad / 492476	ZFINID:	ZDB-GENE-041114-36	Length:	544	Species:	Danio rerio

Alignment Length:	584	Identity:	127/584 - (21%)
Similarity:	220/584 - (37%)	Gaps:	145/584 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VEEFRKYGKEVIDYICQYGTNIEERDVAPTLDPGYLKKLLPADAPQSPEPFKDVLEDFEQKIMPG 67
            :||....|:::.:.:|::            .||..|:.||..:.....|..:.:|:.. :.:...
Zfish    80 MEEILNKGRDLKEKVCEW------------KDPDQLRSLLDLELRDHGECHEKLLQRV-RDVAKY 131

  Fly    68 VVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPKAF 132
            .|...||:||....:|..:.::.|.:::..:.:..:::...|....:|..|::.....:|..:..
Zfish   132 SVKTCHPRFFNQLFAGVDYHALTGRLITETLNTSQYTYEVAPVFVLMEEEVISKLRSLVGWSEGD 196

  Fly   133 VSDAPGSTGGGALQGSASECVLVSLITARARAISEL--KGQTSVHDSVFLPSLIAYASREAHSSV 195
            ....||        ||.|....:::  ||..|..::  ||..:.      |.:..:.|:::|.||
Zfish   197 GIFCPG--------GSMSNMYAINV--ARYWAFPQVKTKGLWAA------PRMAIFTSQQSHYSV 245

  Fly   196 EKATK---MALVKLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDITEI 257
            :|...   :....:.|:..||.|.|..:.|...|....:....||||.||.|||...|||.:..|
Zfish   246 KKGAAFLGIGTENVFIVQVDESGSMIPEDLEAKIVQAKSQDAVPFFVNATAGTTVQGAFDPLKRI 310

  Fly   258 GKVCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALWVRDVMN 322
            ..:|.: :.:|:|||.|:.|:.....:.|...||:|.|:|...||:|:|||....|.:..||..|
Zfish   311 ADICER-NGMWMHVDAAWGGSVLFSKKHRHLVAGIERANSVTWNPHKMLLTGLQCSVILFRDTTN 374

  Fly   323 LKSALNVNPLYLRHEHL--------------TGVDYRHYGIPLSRRFRALKLWFVFRTYGIRGLQ 373
            |          |.|.|.              |.:|.....|...|:...||||.:::..|..||.
Zfish   375 L----------LMHCHSAKATYLFQQDKFYDTSLDTGDKSIQCGRKVDCLKLWLMWKAIGASGLS 429

  Fly   374 EYIRNHMALAKKFEMLVRKDERFEVRNDVHLGLVCFRMRTGDEPNHMLLAQINHSGKMHMTPAKF 438
            :.:....||.:.....:.|.|.|:        |||
Zfish   430 QRVDKAFALTRYLVEEMEKRENFQ--------LVC------------------------------ 456

  Fly   439 NGRYVIRFCVTYEHATEKDILEAWTQIKCFAEEILRDHQLESSSVPTTPEGSERTS--SEPLAPV 501
            .|.:| ..|..:                                :|.:.:|.|.:.  .|.|:.|
Zfish   457 KGPFV-NVCFWF--------------------------------IPPSLKGKENSPDYQERLSKV 488

  Fly   502 AGKPPIKKRLTRTKSLRFSFTRSISREQYQSQSEHLMDGCTPILVVDPKTLQENFQKAADDNDR 565
            |  |.||:|:.:         |......||...||:  ....::||.|:...::.....|:.::
Zfish   489 A--PVIKERMMK---------RGTMMVGYQPMDEHV--NFFRMVVVSPQLTTKDMDFFLDEMEK 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	99/395 (25%)
csad	XP_009295318.1	DOPA_deC_like	140..540	CDD:99743	113/511 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810