DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc1 and Sply

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_652032.1	Gene:	Sply / 46059	FlyBaseID:	FBgn0010591	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	86/486 - (17%)
Similarity:	167/486 - (34%)	Gaps:	120/486 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 KDVLEDFEQKIMPGVVHWNHPK----FFAYFPSGNSFPSVLGDMLSSAIGSIGFS--------WA 106
            :::|...::.:..|..:|...:    .:.|.|.       |.::::...|...::        ..
  Fly   111 EEILRLVDEHLKTGHYNWRDGRVSGAVYGYKPD-------LVELVTEVYGKASYTNPLHADLFPG 168

  Fly   107 SCPAAAELETIVMNWYAKALGLPKAFVSDAPGSTGGGALQGSASECVLVSLITARARAISELKGQ 171
            .|...||:..:..|.:             ...|...|.:....:|.:::::...|..| .|.||.
  Fly   169 VCKMEAEVVRMACNLF-------------HGNSASCGTMTTGGTESIVMAMKAYRDFA-REYKGI 219

  Fly   172 TSVHDSVFLPSLIAYASREAHSSVEKATKMALVKLRIIDAD-EHGRMRVDLLRQAIQND--VNAG 233
            |.       |:::  ..:..|::.:|..:...:.:|.:|.| |...:.:...::||..:  :..|
  Fly   220 TR-------PNIV--VPKTVHAAFDKGGQYFNIHVRSVDVDPETYEVDIKKFKRAINRNTILLVG 275

  Fly   234 LTPFFVVATVGTTGGCAFDDITEIGKVCRQVSSIWLHVDGAYAGNSFILP-------EMRVFSAG 291
            ..|.|...|:        |||..|..:..:. .|.:|||...  .||::.       ::|.|...
  Fly   276 SAPNFPYGTI--------DDIEAIAALGVKY-DIPVHVDACL--GSFVVALVRNAGYKLRPFDFE 329

  Fly   292 LEYADSFNTNPNKLLLTNFDASALWVRDVMNLKSALNVNPLYLRHEHLTGVDYRH--YGIPLSRR 354
            ::...|.:.:.:|.......:|.:...|           ..|..|:.....|:..  ||.|....
  Fly   330 VKGVTSISADTHKYGFAPKGSSVILYSD-----------KKYKDHQFTVTTDWPGGVYGSPTVNG 383

  Fly   355 FRA----LKLWFVFRTYGIRGLQEYIRNHMALAKKFEMLVRKDERFEV-----RNDVHLGLVCFR 410
            .||    ...|....::|..|..|..:..:..|:..|..||..:...:     .:.:.||...|.
  Fly   384 SRAGGIIAACWATMMSFGYDGYLEATKRIVDTARYIERGVRDIDGIFIFGKPATSVIALGSNVFD 448

  Fly   411 M-RTGDEPNHMLLAQINHSGKMHMTPAKFNGRYVIRFCVTYEHATEKDILEAW-TQIKCFAEEIL 473
            : |..|.     |.::..:......|:.      |..|||..| |:..:.:.: ..::....||:
  Fly   449 IFRLSDS-----LCKLGWNLNALQFPSG------IHLCVTDMH-TQPGVADKFIADVRSCTAEIM 501

  Fly   474 RDHQLESSSVPTTPEGSERTSSEPLAPVAGK 504
            :|                     |..||.||
  Fly   502 KD---------------------PGQPVVGK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	68/391 (17%)
Sply	NP_652032.1	DOPA_deC_like	132..494	CDD:99743	75/425 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810