DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc1 and Gad1

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	117/458 - (25%)
Similarity:	188/458 - (41%)	Gaps:	88/458 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EFRKYGKEVIDYICQY--GTNIEERDVAPTLDPGYLKKLLPADAPQSPEPFKDVLED----FEQK 63
            |.|::..:|||.:..:  .||.....|.....|..:|:||..|.|....|.:.::||    .:.:
  Fly    32 ETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQ 96

  Fly    64 IMPGVVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGL 128
            :..|     ||.||....:|....|:.|:.|::...:..|::...|....:|.:|:....:.:|.
  Fly    97 VKTG-----HPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREIIGW 156

  Fly   129 PKAFVSDAPGSTGGGALQGSASECVLVSLITARARAISELKGQTSVHDSVFLP-SLIAYASREAH 192
            .......|||        ||.|.  |.:.:.||.:.....|    .|.||.|| :|:.:.|.:.|
  Fly   157 SGGDSILAPG--------GSISN--LYAFLAARHKMFPNYK----EHGSVGLPGTLVMFTSDQCH 207

  Fly   193 SSVEKATKMALVKLR-----IIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFD 252
            .|::...  |:..|.     ::.:||||:|....|.:.|......|..||||.||.|||...|||
  Fly   208 YSIKSCA--AVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFD 270

  Fly   253 DITEIGKVCRQVSSIWLHVDGAYAGNSFILPEMR--VFSAGLEYADSFNTNPNKLLLTNFDASAL 315
            ||..|..:| |..:.|:|:|.|:.|...:..:.|  .|: |:|.|||...||:||:......|.:
  Fly   271 DINTIADIC-QKYNCWMHIDAAWGGGLLMSRKHRHPRFT-GVERADSVTWNPHKLMGALLQCSTI 333

  Fly   316 WVRDVMNLKSALNVNPLYLRHEHLTGVDY--------------RHYGIPLSRRFRALKLWFVFRT 366
            ..::...|.|...::..||   .:|...|              ||..|        .|||..:|.
  Fly   334 HFKEDGLLISCNQMSAEYL---FMTDKQYDISYDTGDKVIQCGRHNDI--------FKLWLQWRA 387

  Fly   367 YGIRGLQEYIRNHMALAK-KFEMLVRKDERF-------------------------EVRNDVHLG 405
            .|..|.::.....|.|.: :.:.:..:.:||                         :.:.:|.||
  Fly   388 KGTEGFEQQQDRLMELVQYQLKRIREQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELG 452

  Fly   406 LVC 408
            .:|
  Fly   453 KIC 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	109/426 (26%)
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	105/403 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810