DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc1 and GAD1

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_000808.2	Gene:	GAD1 / 2571	HGNCID:	4092	Length:	594	Species:	Homo sapiens

Alignment Length:	439	Identity:	110/439 - (25%)
Similarity:	179/439 - (40%)	Gaps:	78/439 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EVIDYICQYGTNIEERDVAPTLDPGYLKKLLPA------DAPQSPEPFKDVLEDFEQKIMPGVVH 70
            ||:|.:..|.....:|. ...||..:..:||..      :....||..:.:|.|....:..| |.
Human   119 EVVDILLNYVRKTFDRS-TKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYG-VR 181

  Fly    71 WNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETI-------VMNWYAKALGL 128
            ..||:||....:|.....:.|:.|:|...:..|::...|....:|.|       ::.|.:|
Human   182 TGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSSK---- 242

  Fly   129 PKAFVSDAPG-STGGGALQGSASECVLVSLITARARAISEL--KGQTSVHDSVFLPSLIAYASRE 190
                  |..| .:.|||:..      :.|::.||.:...|:  ||..:|      |.|:.:.|.:
Human   243 ------DGDGIFSPGGAISN------MYSIMAARYKYFPEVKTKGMAAV------PKLVLFTSEQ 289

  Fly   191 AHSSVEKA--------TKMALVKL----RIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATV 243
            :|.|::||        ..:.|:|.    :||.||...:     :.:|.|.    |..||:|.||.
Human   290 SHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAK-----ILEAKQK----GYVPFYVNATA 345

  Fly   244 GTTGGCAFDDITEIGKVCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLT 308
            |||...|||.|.||..:|.:. ::|||||.|:.|...:..:.|....|:|.|:|...||:|::..
Human   346 GTTVYGAFDPIQEIADICEKY-NLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGV 409

  Fly   309 NFDASALWVRDVMNLKSALNVNPLYL---RHEHLTGVDYRHYGIPLSRRFRALKLWFVFRTYGIR 370
            ....||:.|::...|:....:...||   ..::....|.....|...|.....|.|.:::..|..
Human   410 LLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTV 474

  Fly   371 GLQEYIRNHMALAKKFEMLVRKDERFEVRNDVHLGLVCFRMRTGDEPNH 419
            |.:..|...:.||:.....::..|.||             |....||.|
Human   475 GFENQINKCLELAEYLYAKIKNREEFE-------------MVFNGEPEH 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	99/407 (24%)
GAD1	NP_000808.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pyridoxal_deC	144..518	CDD:365998	103/413 (25%)
		Substrate binding	190..192		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810