DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc1 and Hdc

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_058712.2	Gene:	Hdc / 24443	RGDID:	2790	Length:	656	Species:	Rattus norvegicus

Alignment Length:	594	Identity:	243/594 - (40%)
Similarity:	356/594 - (59%)	Gaps:	50/594 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVEEFRKY---GKEVIDYICQYGTNIEERDVAPTLDPGYLKKLLPADAPQSPEPFKDVLEDFEQ 62
            |:..|:|:|   |||::||||||.:.:.||.|.|.:.||||:..:|:.||:.|:.:..:..|.||
  Rat     2 MEPSEYREYQARGKEMVDYICQYLSTLRERQVTPNVKPGYLRAQIPSSAPEEPDSWDSIFGDIEQ 66

  Fly    63 KIMPGVVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALG 127
            .||||||||..|...||:|:..|:||:|||||:.||..:||:|||.||..|||..:|:|.||.||
  Rat    67 IIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKMLG 131

  Fly   128 LPKAFVSDAPGSTGGGALQGSASECVLVSLITARARAISELKG-QTSVHDSVFLPSLIAYASREA 191
            ||..|:...|.|.|||.||.:.||..|::|:.||...|.|:|. :.:..:|.....|:||||.:|
  Rat   132 LPDFFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKAHEPNADESSLNARLVAYASDQA 196

  Fly   192 HSSVEKATKMALVKLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDITE 256
            |||||||..::|||::.:..|::..:|.:.|::||:.|...||.|.||.||:||||.||||.::|
  Rat   197 HSSVEKAGLISLVKIKFLPVDDNFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDKLSE 261

  Fly   257 IGKVCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALWVRDVM 321
            :|.:|.: ..:|||||.||||.:|:.||:|.|..|:||||||..||:|.::.:||.:..||:|..
  Rat   262 LGPICAR-EGLWLHVDAAYAGTAFLCPELRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKY 325

  Fly   322 NLKSALNVNPLYLRHEHLTGV--DYRHYGIPLSRRFRALKLWFVFRTYGIRGLQEYIRNHMALAK 384
            .|:...:|||:||||.: :||  |:.|:.||||||||::|||||.|::|::.||.::|:...:||
  Rat   326 KLQQTFSVNPIYLRHAN-SGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTDMAK 389

  Fly   385 KFEMLVRKDERFEVRNDVHLGLVCFRMRTGDEPNHMLLAQINHSGKMHMTPAKFNGRYVIRFCVT 449
            .||.|||.|..||:..:.|||||.||::..:.....:|.:|..:|::.:.||....:.:|||.||
  Rat   390 YFESLVRSDPVFEIPAERHLGLVVFRLKGPNCLTESVLKEIAKTGQVFLIPATIQDKLIIRFTVT 454

  Fly   450 YEHATEKDILEAWTQIKCFAEEILRDHQLESSSVPTTPEGSERTSSEPLAPVAGKPPIKKRLTR- 513
            .:..|:.|||..|..|:..|..:|..|        .|.:.|.|..:  |.|    ||:    ||
  Rat   455 SQFTTKDDILRDWNLIREAANLVLSQH--------CTSQPSPRAKN--LIP----PPV----TRD 501

  Fly   514 TKSLRFSFTRSISREQYQSQSEHLMDGCTPILVVDPKTLQENFQKAADDNDRNNSNGNVKLKDIS 578
            :|.|    |..:|.|......:            ||..:::.|:...|..:       ..:....
  Rat   502 SKDL----TNGLSLESVNEGGD------------DPVQVRKIFRLPGDSLE-------TTMDPFD 543

  Fly   579 DVDTDEASN 587
            |..::|||:
  Rat   544 DCFSEEASD 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	185/379 (49%)
Hdc	NP_058712.2	Pyridoxal_deC	39..417	CDD:278699	185/379 (49%)
Hdc	NP_058712.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..502		10/38 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830