DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc1 and Gad2

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_036695.1	Gene:	Gad2 / 24380	RGDID:	2653	Length:	585	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	108/422 - (25%)
Similarity:	186/422 - (44%)	Gaps:	50/422 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KEVIDYICQYGTNIEERDVAPTLDPGYLKKLLP------ADAPQSPEPFKDVLEDFEQKIMPGVV 69
            ::|::.:.||.....:|. ...:|..|..:||.      ||.||:.|   ::|... |..:...:
  Rat   112 QDVMNILLQYVVKSFDRS-TKVIDFHYPNELLQEYNWELADQPQNLE---EILTHC-QTTLKYAI 171

  Fly    70 HWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPKAFVS 134
            ...||::|....:|.....:..|.|:|...:..|::...|....||.:.:....:.:|.
  Rat   172 KTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGW------ 230

  Fly   135 DAPGSTGGGALQGSASECVLVSLITARARAISEL--KGQTSVHDSVFLPSLIAYASREAHSSVEK 197
              ||.:|.|......:...:.:::.||.:...|:  ||..:|      |.|||:.|..:|.|::|
  Rat   231 --PGGSGDGIFSPGGAISNMYAMLIARYKMFPEVKEKGMAAV------PRLIAFTSEHSHFSLKK 287

  Fly   198 ---ATKMALVKLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDITEIGK 259
               |..:....:.:|..||.|:|....|.:.|......|..||.|.||.|||...|||.:..:..
  Rat   288 GAAALGIGTDSVILIKCDERGKMIPSDLERRILEVKQKGFVPFLVSATAGTTVYGAFDPLLAVAD 352

  Fly   260 VCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALWVRDVMNLK 324
            :|::. .||:|||.|:.|...:..:.:....|:|.|:|...||:|::......|||.||:...::
  Rat   353 ICKKY-KIWMHVDAAWGGGLLMSRKHKWKLNGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQ 416

  Fly   325 SALNVNPLYLRHEHLTGVDYRHYGIPLSRRFRAL---------KLWFVFRTYGIRGLQEYIRNHM 380
            |...::..||..:.      :||.:......:||         |||.::|..|..|.:.:|...:
  Rat   417 SCNQMHASYLFQQD------KHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCL 475

  Fly   381 ALAKKFEMLVRKDERFEVRND---VHLGLVCF 409
            .||:....:::..|.:|:..|   .|.. |||
  Rat   476 ELAEYLYNIIKNREGYEMVFDGKPQHTN-VCF 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	103/398 (26%)
Gad2	NP_036695.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Pyridoxal_deC	138..509	CDD:278699	102/395 (26%)
		Substrate binding. /evidence=ECO:0000250	181..183		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810