DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc1 and Gad1

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_058703.1	Gene:	Gad1 / 24379	RGDID:	2652	Length:	593	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	108/432 - (25%)
Similarity:	175/432 - (40%)	Gaps:	64/432 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EVIDYICQYGTNIEERDVAPTLDPGYLKKLLPA------DAPQSPEPFKDVLEDFEQKIMPGVVH 70
            ||:|.:..|.....:|. ...||..:..:||..      :....||..:.:|.|....:..| |.
  Rat   118 EVVDILLNYVRKTFDRS-TKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYG-VR 180

  Fly    71 WNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPKAFVSD 135
            ..||:||....:|.....:.|:.|:|...:..|::...|....:|.|.:....:.:|...   .|
  Rat   181 TGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIIGWSN---KD 242

  Fly   136 APG-STGGGALQGSASECVLVSLITARARAISEL--KGQTSVHDSVFLPSLIAYASREAHSSVEK 197
            ..| .:.|||:..      :.|::.||.:...|:  ||..:|      |.|:.:.|..:|.|::|
  Rat   243 GDGIFSPGGAISN------MYSIMAARYKYFPEVKTKGMAAV------PKLVLFTSEHSHYSIKK 295

  Fly   198 A--------TKMALVKL----RIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCA 250
            |        ..:.|:|.    :||.||         |...|.:....|..|.:|.||.|||...|
  Rat   296 AGAALGFGTDNVILIKCNERGKIIPAD---------LEAKILDAKQKGFVPLYVNATAGTTVYGA 351

  Fly   251 FDDITEIGKVCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASAL 315
            ||.|.||..:|.:. ::|||||.|:.|...:..:.|...:|:|.|:|...||:|::......||:
  Rat   352 FDPIQEIADICEKY-NLWLHVDAAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVLLQCSAI 415

  Fly   316 WVRDVMNLKSALNVNPLYL---RHEHLTGVDYRHYGIPLSRRFRALKLWFVFRTYGIRGLQEYIR 377
            .|::...|:....:...||   ..::....|.....|...|.....|.|.:::..|..|.:..|.
  Rat   416 LVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQIN 480

  Fly   378 NHMALAKKFEMLVRKDERFEVRNDVHLGLVCFRMRTGDEPNH 419
            ..:.||:.....::..|.||             |....||.|
  Rat   481 KCLELAEYLYAKIKNREEFE-------------MVFNGEPEH 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	97/400 (24%)
Gad1	NP_058703.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Pyridoxal_deC	143..517	CDD:395219	101/406 (25%)
		Substrate binding. /evidence=ECO:0000250	189..191		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810