Protein Alignment Tdc1 and spl-2

DIOPT Version :10

• Sequence 1: NP_610226.2
• Gene: Tdc1 / 35573
• FlyBaseID: FBgn0259977
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_505372.1
• Gene: spl-2 / 181859
• WormBaseID: WBGene00006418
• Length: 542
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 113/574 - (19%)
• Similarity: 198/574 - (34%)
• Gaps: 171/574 - (29%)

  Fly     2 DVEEFRKYGKEVIDYICQYGTNIEERDVAPT-----------LD-PGYLKKLLPADAPQSPEPFK 54
            :|::..:....::|...:|.|.|....|..|           |: |.:|:..: :.|..:.|..|
 Worm    79 EVKDELEKSLRIVDRSTEYFTTIPSHSVGRTEVLRLAAIYDDLEGPAFLEGRV-SGAVFNREDDK 142

  Fly    55 DVLEDFEQKIMPGVVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVM 119
            |..|.:|:..  |...|.:|.:...||......:.:..|..:                     :|
 Worm   143 DEREMYEEVF--GKFAWTNPLWPKLFPGVRIMEAEVVRMCCN---------------------MM 184

  Fly   120 NWYAKALGLPKAFVSDAPGSTGGGALQGSASECVLVSLITARARAISELKGQTSVHDSVFLPSLI 184
            |..::..|..         ||||       |..:|::.:..|.|.:.  :|:.  :..:.:||.:
 Worm   185 NGDSETCGTM---------STGG-------SISILLACLAHRNRLLK--RGEK--YTEMIVPSSV 229

  Fly   185 AYASREAHSSVEKATKMALVKLRIIDADEHGRMRVDLLRQAIQNDVN------AGLTPFFVVATV 243
                   |::..||.:...:|:|.|..|. ...:|||::  ::..:|      .|..|.|...||
 Worm   230 -------HAAFFKAAECFRIKVRKIPVDP-VTFKVDLVK--MKAAINKRTCMLVGSAPNFPFGTV 284

  Fly   244 GTTGGCAFDDITEIGKVCRQVSSIWLHVDGAYAGNSFILP-----EMRVFSAGLEYADSFNTNPN 303
                    |||..||::..:. .|.:|||....|  |:||     |:| :...:....|.:.:.:
 Worm   285 --------DDIEAIGQLGLEY-DIPVHVDACLGG--FLLPFLEEDEIR-YDFRVPGVSSISADSH 337

  Fly   304 KLLLTNFDASALWVRDVMNLKSALNVNPLYLRHEHLTGVDYRHYGIPLSRRFRALK-------LW 361
            |..|....:|.:..|           |...|.:::....|::. ||..|......:       .|
 Worm   338 KYGLAPKGSSVVLYR-----------NKELLHNQYFCDADWQG-GIYASATMEGSRAGHNIALCW 390

  Fly   362 FVFRTYGIRGLQEYIRNHMALAKKFEMLVRKDERFEVRN--------------DVHL-------G 405
            .....:...|       :.|.|:|.....||     :||              ||.:       |
 Worm   391 AAMLYHAQEG-------YKANARKIVDTTRK-----IRNGLSNIKGIKLQGPSDVCIVSWTTNDG 443

  Fly   406 LVCFRMRTGDEPNHMLLAQINHSGKMHMTPAKFNGRYVIRFCVTYEHATEKDILEAWTQIKCFAE 470
            :..:|.....:..|..|..:.....:|:             .||..| |...:.||:......|.
 Worm   444 VELYRFHNFMKEKHWQLNGLQFPAGVHI-------------MVTMNH-THPGLAEAFVADCRAAV 494

  Fly   471 EILRDHQLESSSVPTTPEGSERTSSEPLAPVAGKPPIKKRLTRTKSLRFSFTRS 524
            |.::.|:         |..|::||...:..:|...|       .:||...|..|
 Worm   495 EFVKSHK---------PSESDKTSEAAIYGLAQSIP-------DRSLVHEFAHS 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:395219	83/415 (20%)
spl-2	NP_505372.1	DOPA_deC_like	130..493	CDD:99743	90/466 (19%)