DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc1 and DDC

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_000781.2	Gene:	DDC / 1644	HGNCID:	2719	Length:	480	Species:	Homo sapiens

Alignment Length:	478	Identity:	234/478 - (48%)
Similarity:	327/478 - (68%)	Gaps:	6/478 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVEEFRKYGKEVIDYICQYGTNIEERDVAPTLDPGYLKKLLPADAPQSPEPFKDVLEDFEQKIM 65
            |:..|||:.|||::||:..|...||.|.|.|.::||||:.|:||.|||.|:.|:|::.|.|:.||
Human     1 MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIM 65

  Fly    66 PGVVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPK 130
            |||.||:.|.||||||:.:|:|::|.|||..|||.||||||:.||..||||::|:|..|.|.|||
Human    66 PGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPK 130

  Fly   131 AFVSDAPGSTGGGALQGSASECVLVSLITARARAISELKGQT-SVHDSVFLPSLIAYASREAHSS 194
            ||:::..|. |||.:||||||..||:|:.||.:.|..|:..: .:..:..:..|:||:|.:||||
Human   131 AFLNEKAGE-GGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSS 194

  Fly   195 VEKATKMALVKLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDITEIGK 259
            ||:|..:..|||:.|.:|.:..||...|::|::.|..|||.|||:|||:|||..|:||::.|:|.
Human   195 VERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGP 259

  Fly   260 VCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALWVRDVMNLK 324
            :|.: ..||||||.||||::||.||.|....|:|:|||||.||:|.||.|||.||:||:...:|.
Human   260 ICNK-EDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLT 323

  Fly   325 SALNVNPLYLRHEHLTG---VDYRHYGIPLSRRFRALKLWFVFRTYGIRGLQEYIRNHMALAKKF 386
            .|..::|.||:|.|...   .||||:.|||.||||:||:|||||.||::|||.|||.|:.|:.:|
Human   324 GAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEF 388

  Fly   387 EMLVRKDERFEVRNDVHLGLVCFRMRTGDEPNHMLLAQINHSGKMHMTPAKFNGRYVIRFCVTYE 451
            |.|||:|.|||:..:|.|||||||::..::.|..||.:||.:.|:|:.|.....::|:||.:...
Human   389 ESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSR 453

  Fly   452 HATEKDILEAWTQIKCFAEEILR 474
            ......:..||..||..|.::||
Human   454 TVESAHVQRAWEHIKELAADVLR 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	201/380 (53%)
DDC	NP_000781.2	Pyridoxal_deC	35..414	CDD:365998	201/380 (53%)
DDC	NP_000781.2	2 X approximate tandem repeats	58..178		63/120 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815392	Normalized mean entropy	S2516
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.680