DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc1 and Hdc

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_006498847.1	Gene:	Hdc / 15186	MGIID:	96062	Length:	681	Species:	Mus musculus

Alignment Length:	537	Identity:	225/537 - (41%)
Similarity:	330/537 - (61%)	Gaps:	14/537 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GKEVIDYICQYGTNIEERDVAPTLDPGYLKKLLPADAPQSPEPFKDVLEDFEQKIMPGVVHWNHP 74
            |||::|||.||.:.:.||.|.|.:.||||:..|||.||:.|:.:..:..|.|:.||||||||..|
Mouse    37 GKEMVDYISQYLSTVRERQVTPNVQPGYLRAQLPASAPEEPDSWDSIFGDIERVIMPGVVHWQSP 101

  Fly    75 KFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPKAFVSDAPGS 139
            ...||:|:..|:||:|||||:.||..:||:|||.||..|||..:|:|.||.||||:.|:...|.|
Mouse   102 HMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKMLGLPEYFLHHHPSS 166

  Fly   140 TGGGALQGSASECVLVSLITARARAISELKG-QTSVHDSVFLPSLIAYASREAHSSVEKATKMAL 203
            .|||.||.:.||..|::|:.||...|..:|. :...::|.....|:||.|.:||||||||..::|
Mouse   167 RGGGVLQSTVSESTLIALLAARKNKILAMKACEPDANESSLNARLVAYTSDQAHSSVEKAGLISL 231

  Fly   204 VKLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDITEIGKVCRQVSSIW 268
            ||:|.:..|::..:|.:.|::||:.|...||.|.||.||:||||.||||.::|:|.:|.. ..:|
Mouse   232 VKIRFLPVDDNFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDRLSELGPICAS-EGLW 295

  Fly   269 LHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALWVRDVMNLKSALNVNPLY 333
            ||||.||||.:|:.||:|.|..|:||||||..||:|.::.:||.:..||:|...|:...:|||:|
Mouse   296 LHVDAAYAGTAFLCPELRGFLEGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIY 360

  Fly   334 LRHEHL-TGVDYRHYGIPLSRRFRALKLWFVFRTYGIRGLQEYIRNHMALAKKFEMLVRKDERFE 397
            |||.:. ...|:.|:.||||||||::|||||.|::|::.||.::|:...:||.||.|||.|..||
Mouse   361 LRHANSGAATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRSDPSFE 425

  Fly   398 VRNDVHLGLVCFRMRTGDEPNHMLLAQINHSGKMHMTPAKFNGRYVIRFCVTYEHATEKDILEAW 462
            :....|||||.||::..:.....:|.:|..:|::.:.||....:.:|||.||.:..|::|||..|
Mouse   426 IPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGQLFLIPATIQDKLIIRFTVTSQFTTKEDILRDW 490

  Fly   463 TQIKCFAEEILRDH-----QLESSSVPTTPEGSERTSSEPLAPVAGKPPIKKRLTRTKSLRFSFT 522
            ..|:..|..:|..|     ...:.:|...|.|:...|.|.::.....|...:::.:...
Mouse   491 HLIQEAANLVLSQHCTSQPSPRAKNVIPPPPGTRGLSLESVSEGGDDPAQARKIIKQPG------ 549

  Fly   523 RSISREQYQSQSEHLMD 539
            .|::|.:..|..|.:.|
Mouse   550 ASLARREGGSDLETMPD 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	183/378 (48%)
Hdc	XP_006498847.1	Pyridoxal_deC	62..440	CDD:365998	183/378 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720