DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc1 and gad1a

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_002663350.1	Gene:	gad1a / 100329827	ZFINID:	ZDB-GENE-070912-472	Length:	591	Species:	Danio rerio

Alignment Length:	436	Identity:	107/436 - (24%)
Similarity:	189/436 - (43%)	Gaps:	45/436 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EVIDYICQYGTNIEERDVAPTLDPGYLKKLLPA------DAPQSPEPFKDVLEDFEQKIMPGVVH 70
            ||::.:..|.....:|. ...||..:..:||..      :....||..:.:|.|....:..| |.
Zfish   116 EVVEILTNYVRKTFDRS-TKVLDFHHPHQLLEGMEGFNLELCDQPESLEQILVDCRDTLKYG-VR 178

  Fly    71 WNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAKALGLPKAFVSD 135
            ..||:||....||.....:.|:.|:|...:..|::...|....:|.:.:....:.:|.|.   .:
Zfish   179 TGHPRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIVGWPN---GE 240

  Fly   136 APG-STGGGALQGSASECVLVSLITARARAISELKGQTSVHDSVFLPSLIAYASREAHSSVEKAT 199
            ..| .:.|||:..      :.|::.||.:...|:|    :......|.|:.:.|..:|.|::||:
Zfish   241 GDGIFSPGGAISN------MYSVMVARYKHYPEIK----IKGMAAAPRLVLFTSEHSHYSIKKAS 295

  Fly   200 KMA------LVKLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAFDDITEIG 258
            .:.      |:.||   .||.||:....|...:.:....|..|.||.||.|:|...|||.|.||.
Zfish   296 AVLGFGTENLILLR---TDERGRVIPADLEAKVIDAKQKGFVPMFVNATAGSTVYGAFDPINEIA 357

  Fly   259 KVCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALWVRDVMNL 323
            .:|.:. ::|||||||:.|...:..:.:...:|:|.|:|...||:|::......||:.||:...|
Zfish   358 DICEKY-NMWLHVDGAWGGGLLMSRKHKHKLSGIERANSVTWNPHKMMGVPLQCSAILVREKGLL 421

  Fly   324 KSALNVNPLYL---RHEHLTGVDYRHYGIPLSRRFRALKLWFVFRTYGIRGLQEYIRNHMALAKK 385
            :...::...||   ..::....|.....|...|.....|.|.::::.|..|.:::|...:.|::.
Zfish   422 QGCNSMCAGYLFQPDKQYDVTYDTGDKAIQCGRHVDIFKFWLMWKSKGTTGFEKHIDRCLELSEY 486

  Fly   386 FEMLVRKDERFEV--RNDVHLGLVCF--------RMRTGDEPNHML 421
            ....::..|.:|:  :.:.....|||        .:..|:|..|.|
Zfish   487 LYHKIKNREGYEMVFQGEPQHTNVCFWYIPPSLRLLPDGEEKRHRL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	97/402 (24%)
gad1a	XP_002663350.1	Pyridoxal_deC	141..515	CDD:278699	97/391 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910