DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc1 and gad3

DIOPT Version :9

Sequence 1:	NP_610226.2	Gene:	Tdc1 / 35573	FlyBaseID:	FBgn0259977	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001083039.2	Gene:	gad3 / 100038790	ZFINID:	ZDB-GENE-070424-80	Length:	546	Species:	Danio rerio

Alignment Length:	525	Identity:	123/525 - (23%)
Similarity:	205/525 - (39%)	Gaps:	95/525 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DVEEFRK-YGKEVIDYICQYGTNIEERDVAPTLDPGYLKKL------LPADAPQSPEPFKDVLED 59
            |.||..| :.:|:::.:..|.:...:|. ...||..|..:|      ...:.|..|:..:.:|.|
Zfish    60 DGEEATKHFLQELVNILLAYISKSLKRS-TKVLDFHYPHQLNEGLEGFSLELPDQPDNLEQLLVD 123

  Fly    60 FEQKIMPGVVHWNHPKFFAYFPSGNSFPSVLGDMLSSAIGSIGFSWASCPAAAELETIVMNWYAK 124
            ....:..| |...||:||....:|.....:.|:.|:|...:..|::...|....:|.:|:.....
Zfish   124 CRDTLKYG-VKTGHPRFFNQLSTGLDIVGLAGEWLTSTANTNMFTYEISPVFILMEEVVLRKMHT 187

  Fly   125 ALGLPKAFVSDAPGSTGGGALQGSASECVLVSLITARARAISELKGQTSVHDSVFLPSLIAYASR 189
            .:|.|:        ..|.|......|...|.|::.||......:|    .|....:|.|..:.|.
Zfish   188 IIGWPE--------EDGDGIFCPGGSMSNLYSVLLARFHLFPAVK----THGMCAIPRLAMFTSA 240

  Fly   190 EAHSSVEKATKMALV---KLRIIDADEHGRMRVDLLRQAIQNDVNAGLTPFFVVATVGTTGGCAF 251
            .:|.|::|:..:..:   .:.::..||.|:|....|..:|:...:.||.||:|.||.|||...||
Zfish   241 HSHYSIKKSAAVLGIGTENVIVVRCDERGKMISSELNSSIEEAKSKGLVPFYVNATAGTTVYGAF 305

  Fly   252 DDITEIGKVCRQVSSIWLHVDGAYAGNSFILPEMRVFSAGLEYADSFNTNPNKLLLTNFDASALW 316
            |.:.:|..:|.. ..:|:|||.|:.|...:..:.||...|:|.|.|...||:|::......|.:.
Zfish   306 DPLHKIADICEH-HGLWMHVDAAWGGGLLLSNKHRVKLHGIERAHSVTWNPHKMMGVPLQCSTIL 369

  Fly   317 VRDVMNLKSALNVNPLYLRHEHLTGVDYRHY---------GIPLSRRFRALKLWFVFRTYGIRGL 372
            |:     :..|......|..|:|...| :||         .|...|.....|||.:::..|..|.
Zfish   370 VK-----RKGLLQQCNQLCAEYLFQPD-KHYEVSYDTGDKSIQCGRHVDIFKLWLMWKAKGSEGF 428

  Fly   373 QEYIRNHMALAKKFEMLVRKDERFEVRNDVHL--------GLVCF--------RMRTGDEPNHML 421
            :..: ||  ..:..|.|..|.:|   |.|..|        ..|||        .:..|.|
Zfish   429 ESQV-NH--CLENAEYLYYKLKR---RTDFQLVFKGKPEHSNVCFWYLPKRVQNIPLGPE----- 482

  Fly   422 LAQINHSGKMHMTPAKFNGRYV---------------IRF--CVTYEHATEKDILEAWTQIKCFA 469
                 ...::||...|...:.:               :.|  ||....||:::      .:....
Zfish   483 -----REKELHMVAPKIKTKMMEEGFTMIGYQPLEDKVNFFRCVFSNPATQRE------DVDFLL 536

  Fly   470 EEILR 474
            :||:|
Zfish   537 DEIVR 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc1	NP_610226.2	Pyridoxal_deC	35..412	CDD:278699	101/410 (25%)
gad3	NP_001083039.2	Pyridoxal_deC	96..469	CDD:278699	100/398 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810