DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsepi and glceb

DIOPT Version :9

Sequence 1:	NP_610249.2	Gene:	Hsepi / 35569	FlyBaseID:	FBgn0033087	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_005168896.1	Gene:	glceb / 100007670	ZFINID:	ZDB-GENE-040630-8	Length:	586	Species:	Danio rerio

Alignment Length:	591	Identity:	263/591 - (44%)
Similarity:	361/591 - (61%)	Gaps:	32/591 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RLNLKAVLLVLTVAVVVITLGVYMRCA---AFSFSPDFVRP-----LDRSARQSSS-------GG 93
            |::.| .|:|:...:.::|:.::.:|.   |..|.|...:|     :|...:|...       ||
Zfish     8 RVHYK-TLIVICALLSLLTVLLWNKCTSEKALRFLPRHPQPPPSPKIDSHPQQPQPPEPPPVVGG 71

  Fly    94 EATALHDIECSINQEYTVHCKRDENANEVYVPFSFLRNYFDVSGAVSTNSNEVAKFNWVHSTAKV 158
              ....:|:|.||.:.|:..:|:  .:|||:|||::..||:|.|.| ...:...:|.:.||.:||
Zfish    72 --VRYEEIDCLINDDATIKGRRE--GSEVYMPFSWMEKYFEVYGKV-VQYDGYDRFEFSHSYSKV 131

  Fly   159 NLPRGKYDARGVYMYFENYNVEVRDRVKCISAAEGVPVSTQWEKRGYFYPTQIAQFALSHYSKNL 223
            ...|.:|...||:|.||.|||||||||||||..||||:||||..:||||..||||:.||||||||
Zfish   132 YAQREQYHPNGVFMSFEGYNVEVRDRVKCISGVEGVPLSTQWGPQGYFYAIQIAQYGLSHYSKNL 196

  Fly   224 TEPAPRVRV---LEDGDGNQMEWSTPKTSNMTRIWHHKFNTSVVQFETAPGYEGVISIALNQTLD 285
            ||..|.|.|   .|:.|.....|:.||..::||::.....|||.||......||| |:.|..|.|
Zfish   197 TERPPHVEVYDTAEERDSRSSAWTVPKGCSLTRVYDKTRATSVRQFSAPENSEGV-SLPLGNTKD 260

  Fly   286 LLLSVDLLLVTNSSSLMITVQNRDTRHNYSLHYIPADLLLSVQDTNIYYGLGGSALNKWRHITRD 350
            .::|.||.. |::.|:.:.::..:....:.:||:....|:.::|.:|.||:|  ....|..:|||
Zfish   261 FIISFDLKF-TSNGSVSVILETTEKGPPFVIHYVTTTQLILLKDRDITYGIG--PRTTWTTVTRD 322

  Fly   351 LHIDLQKGI-MGDKRSPLKIRRSDLEVISIGFLGLGFFDNITLSTSDHLAHFYDAAEWFVHNQDP 414
            |..||:||| :.:.::....:.....|:.:...|.|..||||:||:.|:|.||.|::|.|.|||.
Zfish   323 LLTDLRKGIGLSNTKAVKATKTMPRRVVKLVVHGTGTIDNITISTTSHMAAFYAASDWLVRNQDE 387

  Fly   415 KTGGWTNPVRRSL-NGFAELRPGWISAMGQGHAISVLARAYWHSGGDERYLRAAAAGLQPYRVYS 478
            : |||...|.|.| .||..|.|||.|||.||.|:|.|.|||..: .|:.||:||.....|:::.|
Zfish   388 R-GGWPIMVTRKLGEGFRALEPGWYSAMAQGQAMSTLVRAYLMT-KDDTYLKAALRATGPFKLPS 450

  Fly   479 RDGGVLAQFMDKFYWYEEYPTTPPSYVLNGFIYSLLGLYDLNSTAPGKIAREAGKLFAQGMHSLK 543
            ...||.|.||:|:.|||||||.|.|:|||||||||:||:||..||..|:.|:||:|:::||.|||
Zfish   451 EQHGVKAVFMNKYDWYEEYPTIPSSFVLNGFIYSLIGLFDLAQTAGEKLGRDAGQLYSKGMESLK 515

  Fly   544 KMLLLFDTGSGTSYDLRHLSLGVAPNLARWDYHATHVNQLLLLATIDSDPLIAQTAERWKGYMFG 608
            .||.|:||||||.|||||..||.||||||||||.||:|||.||.|||:.|:...:.:|||.|:.|
Zfish   516 VMLPLYDTGSGTIYDLRHFILGTAPNLARWDYHTTHINQLQLLGTIDNSPIFRDSVKRWKSYLKG 580

  Fly   609 RRAKHN 614
            .|||||
Zfish   581 GRAKHN 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsepi	NP_610249.2	C5-epim_C	415..604	CDD:284151	109/189 (58%)
glceb	XP_005168896.1	C5-epim_C	385..576	CDD:284151	111/192 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582089
Domainoid	1	1.000	246	1.000	Domainoid score	I2131
eggNOG	1	0.900	-	-		E1_KOG3760
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14111
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1435
OMA	1	1.010	-	-		QHG49344
OrthoDB	1	1.010	-	-		D257141at33208
OrthoFinder	1	1.000	-	-		FOG0006406
OrthoInspector	1	1.000	-	-		otm25555
orthoMCL	1	0.900	-	-		OOG6_106888
Panther	1	1.100	-	-	LDO	PTHR13174
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2543
SonicParanoid	1	1.000	-	-		X4669
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800