DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dpit47 and CNS1

DIOPT Version :9

Sequence 1:	NP_001260729.1	Gene:	Dpit47 / 35565	FlyBaseID:	FBgn0266518	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_009713.1	Gene:	CNS1 / 852452	SGDID:	S000000359	Length:	385	Species:	Saccharomyces cerevisiae

Alignment Length:	410	Identity:	105/410 - (25%)
Similarity:	180/410 - (43%)	Gaps:	68/410 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKQMAAQKAWTDEERL-------ELAAQLDAELDAFIDGLEKKRYEEGWPEDRWQEEMDKHPFFM 58
            |..:.|...:|..::.       ||..||....|...|.:.|              ||::.||||
Yeast     1 MSSVNANGGYTKPQKYVPGPGDPELPPQLSEFKDKTSDEILK--------------EMNRMPFFM 51

  Fly    59 KRAPQP----GDDVHPMFEGLQKLKYDPEENTRDELALNYKEDGNFYMKHKKFRMAIYSFTEGIK 119
            .:..:.    |::|.  .|.|:.|.|:.|.:   |:|.|:|:.||...|.|:|:.|...:::|:.
Yeast    52 TKLDETDGAGGENVE--LEALKALAYEGEPH---EIAENFKKQGNELYKAKRFKDARELYSKGLA 111

  Fly   120 TKTDNPDVLAVLYNNRSAAHFFIKNYRSSLSDAQRALFYKPDYTKARWRSAQCAYELERFD---- 180
            .:.::..:...||.||:|....:||||..:.|..:||...|...|..:|:::..::|.:.:
Yeast   112 VECEDKSINESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKS 176

  Fly   181 ---LCTQMCEELLEVDVDNEVAIALLHKNKMKKLEIERNQRKEAAEAKRRLTRFHRLRDAIEQRA 242
               ...|      .:|.:|:..:.:|.....|:.|::..:.|:..||:.|..:...|..|:..|.
Yeast   177 AATFANQ------RIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQERENKKIMLESAMTLRN 235

  Fly   243 IKFDDQKVGKKDVLSEELLYPKFLPLEDHPVHLDEDGSTLIWPAAFSYP---EFLYSDFYQQLPE 304
            |      ...|.....|||....:.||| |:..:   |.||:||...||   ||   ||..::.|
Yeast   236 I------TNIKTHSPVELLNEGKIRLED-PMDFE---SQLIYPALIMYPTQDEF---DFVGEVSE 287

  Fly   305 TTTMRDCLATLL---TEKLPYDKAHNYRLGNVHVYYENRKVGCVHKVDEEKQLAEIIAEKGFFVS 366
            .||:::.:..:|   .|:...:...|:....|.|:.|. |.|.:.|..::....:|:.::...|.
Yeast   288 LTTVQELVDLVLEGPQERFKKEGKENFTPKKVLVFMET-KAGGLIKAGKKLTFHDILKKESPDVP 351

  Fly   367 --GGALLFYVVHKDSRVEQE 384
              ..||..|:|.|   ||.|
Yeast   352 LFDNALKIYIVPK---VESE 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dpit47	NP_001260729.1	3a0801s09	84..>179	CDD:273380	27/94 (29%)
		TPR repeat	91..119	CDD:276809	10/27 (37%)
		TPR repeat	124..158	CDD:276809	12/33 (36%)
		TPR repeat	163..191	CDD:276809	4/34 (12%)
		TPR repeat	197..227	CDD:276809	6/29 (21%)
CNS1	NP_009713.1	3a0801s09	68..>218	CDD:273380	40/158 (25%)
		TPR repeat	83..111	CDD:276809	10/27 (37%)
		TPR repeat	120..150	CDD:276809	12/29 (41%)
		Wheel	257..374	CDD:408742	35/123 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0551
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31249
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1470
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53786
OrthoFinder	1	1.000	-	-		FOG0005229
OrthoInspector	1	1.000	-	-		oto99709
orthoMCL	1	0.900	-	-		OOG6_102484
Panther	1	1.100	-	-	LDO	PTHR46035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R218
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860