Protein Alignment Dpit47 and TTC4

DIOPT Version :10

• Sequence 1: NP_525106.2
• Gene: Dpit47 / 35565
• FlyBaseID: FBgn0266518
• Length: 396
• Species: Drosophila melanogaster
• Sequence 2: NP_004614.3
• Gene: TTC4 / 7268
• HGNCID: 12394
• Length: 387
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 122/374 - (32%)
• Similarity: 196/374 - (52%)
• Gaps: 8/374 - (2%)

  Fly    23 DAELDAFIDGLEKKRYEEGWPEDRWQEEMDKHPFFMKRAPQPGDD-VHPMFEGLQKLKYDPEENT 86
            |..:|:|::..:.:.|..|:.||:|::|.:|.|.||.|||...|. .:|....||.:.:| ||.:
Human    11 DDVMDSFLEKFQSQPYRGGFHEDQWEKEFEKVPLFMSRAPSEIDPRENPDLACLQSIIFD-EERS 74

  Fly    87 RDELALNYKEDGNFYMKHKKFRMAIYSFTEGIKTKTDNPDVLAVLYNNRSAAHFFIKNYRSSLSD 151
            .:|.|..||::||.|.|.|.::.|:.|:|||:|.|..:||:.||||.||:||.:::.|:||:|:|
Human    75 PEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLNAVLYTNRAAAQYYLGNFRSALND 139

  Fly   152 AQRALFYKPDYTKARWRSAQCAYELERFDLCTQMCEELLEVDVDNEVAIALLHK-NKMKKLEIER 215
            ...|...||.:.||..|.|.|..||:.|......|:|.|::|...:..:.:..| :|:|::| :|
Human   140 VTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIE-QR 203

  Fly   216 NQRKEAAEAKRRLTRFHRLRDAIEQRAIKFDDQKVGKKDVLSEEL--LYPKFLPLED-HPVHLDE 277
            :.||...:.|:...:...|..||:.|.|:..:.....:|..||.|  |:...|..|: |...|..
Human   204 DVRKANLKEKKERNQNEALLQAIKARNIRLSEAACEDEDSASEGLGELFLDGLSTENPHGARLSL 268

  Fly   278 DG-STLIWPAAFSYPEFLYSDFYQQLPETTTMRDCLATLLTEKLPYDKAHNYRLGNVHVYYENRK 341
            || ..|.||..|.|||:..|||.....|.:...|.|..:..|...:|....|...|:.||:|:..
Human   269 DGQGRLSWPVLFLYPEYAQSDFISAFHEDSRFIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDED 333

  Fly   342 VGCVHKVDEEKQLAEIIAEKGFFVSGGALLFYVVHKDSRVEQEFINERR 390
            ...:::|..:..|.:::..:.:||......|.|....|...:.|:..|:
Human   334 RAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLRGRK 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dpit47	NP_525106.2	3a0801s09	84..>179	CDD:273380	42/94 (45%)
		TPR repeat	91..119	CDD:276809	13/27 (48%)
		TPR repeat	124..158	CDD:276809	16/33 (48%)
		TPR repeat	163..191	CDD:276809	10/27 (37%)
		TPR repeat	197..227	CDD:276809	8/30 (27%)
		CTWD_Cns1	232..387	CDD:439174	44/158 (28%)
TTC4	NP_004614.3	NlpI	<64..>181	CDD:443815	50/117 (43%)
		TPR 1	79..112		15/32 (47%)
		TPR repeat	79..107	CDD:276809	13/27 (48%)
		TPR repeat	116..146	CDD:276809	14/29 (48%)
		TPR 2	117..150		16/32 (50%)
		TPR 3	151..184		12/32 (38%)
		TPR repeat	151..179	CDD:276809	10/27 (37%)
		CTWD_Cns1	220..379	CDD:439174	44/158 (28%)