DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dpit47 and TTC12

DIOPT Version :9

Sequence 1:	NP_001260729.1	Gene:	Dpit47 / 35565	FlyBaseID:	FBgn0266518	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	XP_005271661.1	Gene:	TTC12 / 54970	HGNCID:	23700	Length:	777	Species:	Homo sapiens

Alignment Length:	404	Identity:	82/404 - (20%)
Similarity:	148/404 - (36%)	Gaps:	97/404 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QKAWTDEERLELAAQLDAELDAFIDGLEKKRYEEGWPEDRWQEEMDKHPFFMKRAPQPGDDVHPM 71
            |||..:.|:..|..:.|.|.|.....|.|..........:..||::...|
Human    35 QKAVLETEKRLLLMEEDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAF--------------- 84

  Fly    72 FEGLQKLKYDPEENTRDE-----LALNYKEDGNFYMKHKKFRMAIYSFTEGIKTKTDNPDVLAVL 131
               |..::.|.:|..:..     ||...||.||.......:..||..::||::...|    :.||
Human    85 ---LASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKD----MKVL 142

  Fly   132 YNNRSAAHFFIKNYRSSLSDAQRALFYKPDYTKARWRSAQCAYELERFDLCTQMCEELLEVDVDN 196
            |.||:.|:..:::|..:|.|.:.||......|||.:...:....|:.:.:..:..:::||::...
Human   143 YTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKL 207

  Fly   197 EVAIALLHKNKMKKLEIERN---QRKEAAEAKRRLTRFHRLRDAIEQRAIKFDDQKVGKKDVLSE 258
            :..:    |..:.:::::..   |.|||          |.|.|:.:..|       |..|::| |
Human   208 QTQV----KGYLNQVDLQEKADLQEKEA----------HELLDSGKNTA-------VTTKNLL-E 250

  Fly   259 ELLYPKFLPLEDHPVHLDEDGSTLIWPAAFSYPE---FLYSDFYQQLPETTTMRDCLATLLTEKL 320
            .|..|..:||      ....|..::........|   |...:.:..:.:...:|.|.:|
Human   251 TLSKPDQIPL------FYAGGIEILTEMINECTEQTLFRMHNGFSIISDNEVIRRCFST------ 303

  Fly   321 PYDKAHNYRLGNVHV------------------YYENRKVGCVHKVDEEKQLAEIIAEKGFFV-- 365
                     .||..|                  ..||::|..:|. |..:.||.:::.|...:
Human   304 ---------AGNDAVEEMVCVSVLKLWQAVCSRNEENQRVLVIHH-DRARLLAALLSSKVLAIRQ 358

  Fly   366 SGGALLFYVVHKDS 379
            ...|||.::...:|
Human   359 QSFALLLHLAQTES 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dpit47	NP_001260729.1	3a0801s09	84..>179	CDD:273380	27/99 (27%)
		TPR repeat	91..119	CDD:276809	9/27 (33%)
		TPR repeat	124..158	CDD:276809	11/33 (33%)
		TPR repeat	163..191	CDD:276809	4/27 (15%)
		TPR repeat	197..227	CDD:276809	5/32 (16%)
TTC12	XP_005271661.1	TPR_11	106..171	CDD:290150	21/68 (31%)
		BamD	106..>164	CDD:276939	19/61 (31%)
		TPR repeat	106..138	CDD:276939	9/31 (29%)
		TPR repeat	106..134	CDD:276809	9/27 (33%)
		TPR repeat	139..169	CDD:276809	11/29 (38%)
		TPR_11	142..205	CDD:290150	16/62 (26%)
		TPR_1	143..173	CDD:278916	9/29 (31%)
		TPR repeat	174..202	CDD:276809	4/27 (15%)
		TPR repeat	211..236	CDD:276809	7/38 (18%)
		ARM	526..631	CDD:237987
		armadillo repeat	555..591	CDD:293788
		armadillo repeat	597..631	CDD:293788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R218
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940