DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dpit47 and ttc4

DIOPT Version :9

Sequence 1:	NP_001260729.1	Gene:	Dpit47 / 35565	FlyBaseID:	FBgn0266518	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001002122.2	Gene:	ttc4 / 393981	ZFINID:	ZDB-GENE-040426-1021	Length:	402	Species:	Danio rerio

Alignment Length:	395	Identity:	124/395 - (31%)
Similarity:	206/395 - (52%)	Gaps:	38/395 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DAELDAFIDGLEKKRYEEGWPEDRWQEEMDKHPFFMKRAPQPGD-DVHPMFEGLQKLKYDPEENT 86
            |..:|.|::..:.::|...:.|..|:||.:|.|.|||.||:..| :.||....:|.:.:| ::.|
Zfish    11 DDGMDEFMEKFKTQKYHNAFNESNWEEEFEKVPMFMKTAPENIDPEKHPDLACIQHIIHD-DDRT 74

  Fly    87 RDELALNYKEDGNFYMKHKKFRMAIYSFTEGIKTKTDNPDVLAVLYNNRSAAHFFIKNYRSSLSD 151
            .:|.|.:.|::||.|.|.||::.|:.|:|||:||...||::.||||.||:||||.:.|.||:|:|
Zfish    75 PEEKARSLKDEGNEYFKEKKYKKAVVSYTEGLKTSCVNPELNAVLYTNRAAAHFHLGNMRSALND 139

  Fly   152 AQRALFYKPDYTKARWRSAQCAYELERFDLCTQMCEELLEV-DVDNEVAIALLHKNKMKKLEIER 215
            |..|...|||:.||..|.|||..||..:....|.|:|.|:: ..|.::.......:|.|: |.:|
Zfish   140 ATAAKKLKPDHNKAIIRGAQCLLELRNYAGALQWCDEGLKLFPTDKKLQELRATADKQKR-EADR 203

  Fly   216 NQRKEAAEAKRRLTRFHRLRDAIEQRAIKF----------DDQKVGKKD--------------VL 256
            :.||...:||::......|..||::|.||.          .|.:...:|              :.
Zfish   204 DARKAKVKAKKQQNEKEALLAAIKERGIKLLKTEKPPHRASDSEDEDRDEDTSRALADLQLDGIS 268

  Fly   257 SEELLYPKFLPLEDHPVHLDEDGSTLIWPAAFSYPEFLYSDFYQQLPETTTMRDCLATLLTEKL- 320
            |:|....:        |::||.| .|.||..|.|||...:||.....|..:..|.||.:..|:|
Zfish   269 SQEATGAR--------VYMDEQG-VLHWPVMFLYPEHSQTDFISAFSENASFIDHLAVMFGEELP 324

  Fly   321 PYDKAHNYRLGNVHVYYENRKVGCVHKVDEEKQLAEIIAEKGFFVSGGALLFYVVHKDSRVEQEF 385
            |:|....|:..|:.:::|:.:.|.:::||.::.|..::..:...|..|...|.|:..:|...::|
Zfish   325 PWDIDQKYQPQNLQMFFEDPEKGNLYQVDLQESLLRVLQHQRCSVKAGTPSFIVLVSESPFSRQF 389

  Fly   386 INERR 390
            ::.::
Zfish   390 LSGKK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dpit47	NP_001260729.1	3a0801s09	84..>179	CDD:273380	47/94 (50%)
		TPR repeat	91..119	CDD:276809	13/27 (48%)
		TPR repeat	124..158	CDD:276809	19/33 (58%)
		TPR repeat	163..191	CDD:276809	11/27 (41%)
		TPR repeat	197..227	CDD:276809	8/29 (28%)
ttc4	NP_001002122.2	PLN03088	40..>171	CDD:330826	59/131 (45%)
		TPR repeat	79..107	CDD:276809	13/27 (48%)
		TPR repeat	116..146	CDD:276809	17/29 (59%)
		TPR repeat	151..179	CDD:276809	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585527
Domainoid	1	1.000	195	1.000	Domainoid score	I3094
eggNOG	1	0.900	-	-		E2759_KOG0551
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31249
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3807
OMA	1	1.010	-	-		QHG53786
OrthoDB	1	1.010	-	-		D486370at33208
OrthoFinder	1	1.000	-	-		FOG0005229
OrthoInspector	1	1.000	-	-		oto39224
orthoMCL	1	0.900	-	-		OOG6_102484
Panther	1	1.100	-	-	LDO	PTHR46035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R218
SonicParanoid	1	1.000	-	-		X5599
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800