DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dpit47 and Ttc4

DIOPT Version :9

Sequence 1:	NP_001260729.1	Gene:	Dpit47 / 35565	FlyBaseID:	FBgn0266518	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001381972.1	Gene:	Ttc4 / 362556	RGDID:	1308529	Length:	386	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	125/378 - (33%)
Similarity:	199/378 - (52%)	Gaps:	15/378 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DAELDAFIDGLEKKRYEEGWPEDRWQEEMDKHPFFMKRAPQPGDDVH-PMFEGLQKLKYDPEENT 86
            |:.:|||:|..:.:.|..|:.||:|:||.||.|.|||:||...|... |....||.:.:| :|.:
  Rat    11 DSSMDAFLDKFQSQPYRGGFREDQWEEEFDKIPLFMKKAPSEIDPKEFPDLACLQSIIFD-DERS 74

  Fly    87 RDELALNYKEDGNFYMKHKKFRMAIYSFTEGIKTKTDNPDVLAVLYNNRSAAHFFIKNYRSSLSD 151
            .:|.|..||::||.|.|.|.::.|:.|::||:|.|..:||:.|:||.||:||.:::.|:||:|:|
  Rat    75 PEEQAKTYKDEGNDYFKEKDYKKAVVSYSEGLKKKCADPDLNAILYTNRAAAQYYLGNFRSALND 139

  Fly   152 AQRALFYKPDYTKARWRSAQCAYELERFDLCTQMCEELLEVDVDNEVAIALLHK-NKMKKLEIER 215
            ...|...|||:.||..|.|.|..||:.|......|:|.|::|...:..:.:..| :|:|::| ||
  Rat   140 VLAAKKLKPDHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRME-ER 203

  Fly   216 NQRKEAAEAKRRLTRFHRLRDAIEQRAIKFDDQKVGK-----KDVLSEELLYPKFLPLEDHP--V 273
            :.||...:.|:...:...|..||:.|.|:...:.||:     .:.|:|.||:..   ..::|  .
  Rat   204 DLRKAKLKEKKEQNQNEALLQAIKARNIRLVSESVGEDEDSASNGLAEMLLHGL---SSENPCGA 265

  Fly   274 HLDEDG-STLIWPAAFSYPEFLYSDFYQQLPETTTMRDCLATLLTEKLPYDKAHNYRLGNVHVYY 337
            .|..|| ..|.||..|.|||:..|||.....|.|...|.|..:.:|...:|..|.|...::.||:
  Rat   266 RLSIDGQGRLSWPVLFLYPEYAQSDFISAFHEDTRFIDHLMAMFSEAPSWDSEHKYHPDDLEVYF 330

  Fly   338 ENRKVGCVHKVDEEKQLAEIIAEKGFFVSGGALLFYVVHKDSRVEQEFINERR 390
            |:.....:::|..|..|.:::......|......|.|....|...:.|:..:|
  Rat   331 EDEDRAELYQVSPESTLLQVLQHPRCSVKALTPAFLVCVGSSPFCKNFLQGKR 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dpit47	NP_001260729.1	3a0801s09	84..>179	CDD:273380	41/94 (44%)
		TPR repeat	91..119	CDD:276809	12/27 (44%)
		TPR repeat	124..158	CDD:276809	15/33 (45%)
		TPR repeat	163..191	CDD:276809	10/27 (37%)
		TPR repeat	197..227	CDD:276809	9/30 (30%)
Ttc4	NP_001381972.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344446
Domainoid	1	1.000	197	1.000	Domainoid score	I3003
eggNOG	1	0.900	-	-		E2759_KOG0551
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	197	1.000	Inparanoid score	I3728
OMA	1	1.010	-	-		QHG53786
OrthoDB	1	1.010	-	-		D486370at33208
OrthoFinder	1	1.000	-	-		FOG0005229
OrthoInspector	1	1.000	-	-		oto97312
orthoMCL	1	0.900	-	-		OOG6_102484
Panther	1	1.100	-	-	LDO	PTHR46035
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5599
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770