DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dpit47 and cns1

DIOPT Version :9

Sequence 1:	NP_001260729.1	Gene:	Dpit47 / 35565	FlyBaseID:	FBgn0266518	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_594238.1	Gene:	cns1 / 2542172	PomBaseID:	SPAC17A2.04c	Length:	358	Species:	Schizosaccharomyces pombe

Alignment Length:	371	Identity:	88/371 - (23%)
Similarity:	158/371 - (42%)	Gaps:	48/371 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LAAQLDAELDAFIDGLEKKRYEEGWPEDRWQEEMDKHPFFMKRAPQPGDDV--HPMFEGLQKLKY 80
            :|....:|:|   ...:.|..||.:      .|::|.||||:.....||:.  :...:.|:.|.|
pombe     1 MAGFQSSEVD---PNTKNKNAEEMF------NELNKVPFFMQSLEDVGDESENNVQLDALKALAY 56

  Fly    81 DPEENTRDELALNYKEDGNFYMKHKKFRMAIYSFTEGIKTKTDNPDVLAVLYNNRSAAHFFIKNY 145
            :.|.:   |:|.|::|.||.....|:::.|...:|:.:..|..:.|:....|:||:|.:...:||
pombe    57 EGEPH---EVAQNFREHGNECFASKRYKDAEEFYTKALAQKCGDKDIEIACYSNRAACNLLFENY 118

  Fly   146 RSSLSDAQRALFYKPDYTKARWRSAQCAYELERFDLCTQMCEELLEVDVDNEVAIALLHKNKMKK 210
            |..|:|..:.|.....:.||.:|||:....|:|:|...: |..|..:...|:.||..|.|...||
pombe   119 RQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKE-CIRLCSLVHPNDPAILALSKELQKK 182

  Fly   211 L-EIERNQRKEAAEAKRRLTRFHRLRDAIEQRAIKFDDQKVGKKDVLSEELLYPKFLPLEDHPVH 274
            . :.|:.:.::...|:.::.....:..|:::|.||                     ....:||..
pombe   183 SDDFEKRESEKKRVAQEKVIAAKTVLLALQERHIK---------------------TKTTEHPPD 226

  Fly   275 L----------DEDGSTLIWPAAFSYPEFLYSDFYQQLPETTTMRDCLATLLTEKLPYDKAHNYR 329
            |          |:..|.|.:|....||....|||...:.|..|..:.|.|:.....|:|....|.
pombe   227 LGDAMISLSTFDDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVFQSPAPWDVHQLYN 291

  Fly   330 LGNVHVYYENRKVGCVHKVDEEKQLAEIIAEKGFFVSGGALLFYVV 375
            ..::.|:.....:|.: ||.:...:.:.:......:..|.:..:||
pombe   292 PDSLDVFATTDTLGLI-KVGKNVPILKALTHPKVTLIDGLVQLHVV 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dpit47	NP_001260729.1	3a0801s09	84..>179	CDD:273380	27/94 (29%)
		TPR repeat	91..119	CDD:276809	8/27 (30%)
		TPR repeat	124..158	CDD:276809	11/33 (33%)
		TPR repeat	163..191	CDD:276809	10/27 (37%)
		TPR repeat	197..227	CDD:276809	8/30 (27%)
cns1	NP_594238.1	TPR_11	64..132	CDD:290150	20/67 (30%)
		TPR repeat	64..92	CDD:276809	8/27 (30%)
		TPR repeat	97..131	CDD:276809	11/33 (33%)
		TPR_19	116..175	CDD:291240	19/59 (32%)
		TPR repeat	136..160	CDD:276809	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0551
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31249
Inparanoid	1	1.050	98	1.000	Inparanoid score	I1675
OMA	1	1.010	-	-		QHG53786
OrthoFinder	1	1.000	-	-		FOG0005229
OrthoInspector	1	1.000	-	-		oto101367
orthoMCL	1	0.900	-	-		OOG6_102484
Panther	1	1.100	-	-	LDO	PTHR46035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R218
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860