DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dpit47 and Ttc12

DIOPT Version :9

Sequence 1:	NP_001260729.1	Gene:	Dpit47 / 35565	FlyBaseID:	FBgn0266518	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_766358.1	Gene:	Ttc12 / 235330	MGIID:	2444588	Length:	704	Species:	Mus musculus

Alignment Length:	296	Identity:	68/296 - (22%)
Similarity:	121/296 - (40%)	Gaps:	53/296 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QKAWTDEERLELAAQLDAELDAFIDGLEKKRYEEGWPEDRWQEEMDKHPFFMKRAPQPGDDVHP- 70
            |:..:|:..::..|.||:|....:  :|:::.|:|     .:..::|......:.|:..|::.|
Mouse    24 QEMNSDDPFIQQKAVLDSEKKLLL--MEREQEEDG-----CRTTLNKTMISPPQTPENADEMSPD 81

  Fly    71 MFEGLQKLKYDPEENTRDE-----LALNYKEDGNFYMKHKKFRMAIYSFTEGIKTKTDNPDVLAV 130
            .|  |..::.|.:|..:..     ||...||.||.......:..||:.::||:....|    :.|
Mouse    82 AF--LASVEKDAKERAKRRRENRVLADALKEKGNEAFVRGDYETAIFFYSEGLGKLKD----MKV 140

  Fly   131 LYNNRSAAHFFIKNYRSSLSDAQRALFYKPDYTKARWRSAQCAYELERFDL---CTQMCEEL--- 189
            ||.||:.|...:.:|:.:|.|...||....:.|||.:...:....|:.:..   |.|..||:
Mouse   141 LYTNRAQAFIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHVALKNYSKAKECYQKIEEINPK 205

  Fly   190 LEVDVDNEVAIALLHKNKMKKLEIERNQRKEAAEA----KRRLTRFHRLRDAIE---QRAIKFDD 247
            |:..|..       |.|::...|....|.|||.|:    |........|.:.:.   |..:.:
Mouse   206 LKAQVKE-------HLNQVTLREKADLQEKEAQESLDSGKNTAVTTKNLLETLSKPGQTPLFY-- 261

  Fly   248 QKVGKKDVLSEEL----------LYPKFLPLEDHPV 273
              .|..::|:|.:          .|..|..:.||.|
Mouse   262 --AGGIEILTEMMADCTERTLFRTYGGFSTISDHEV 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dpit47	NP_001260729.1	3a0801s09	84..>179	CDD:273380	27/99 (27%)
		TPR repeat	91..119	CDD:276809	9/27 (33%)
		TPR repeat	124..158	CDD:276809	11/33 (33%)
		TPR repeat	163..191	CDD:276809	8/33 (24%)
		TPR repeat	197..227	CDD:276809	9/33 (27%)
Ttc12	NP_766358.1	TPR_11	105..170	CDD:290150	21/68 (31%)
		TPR 1	105..138		10/36 (28%)
		TPR repeat	105..133	CDD:276809	9/27 (33%)
		TPR repeat	138..168	CDD:276809	11/29 (38%)
		TPR 2	139..172		11/32 (34%)
		TPR_11	141..204	CDD:290150	18/62 (29%)
		TPR_1	142..172	CDD:278916	9/29 (31%)
		TPR 3	173..206		8/32 (25%)
		TPR repeat	173..198	CDD:276809	5/24 (21%)
		TPR_1	174..205	CDD:278916	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R218
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940