DRSC/TRiP Functional Genomics Resources

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Protein Alignment geminin and Mcidas

DIOPT Version :9

Sequence 1:NP_001260727.1 Gene:geminin / 35563 FlyBaseID:FBgn0033081 Length:192 Species:Drosophila melanogaster
Sequence 2:NP_001033003.1 Gene:Mcidas / 622408 MGIID:3648807 Length:379 Species:Mus musculus


Alignment Length:134 Identity:34/134 - (25%)
Similarity:60/134 - (44%) Gaps:40/134 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 PAIST---------KDA--DTQTDAEAV---PLGNADKPITAEDLTSTAE--------------- 112
            |::.|         :||  |...|:.::   ||.|:|.|.:..|::|...               
Mouse   104 PSLQTEEDFNLQNFRDAMDDLIADSSSLMSPPLTNSDFPFSPCDVSSFGSCLSPSLDPPALGSPD 168

  Fly   113 ----PGENYYKLLAEQRRLALEDSLTENRHLHERIEGLEEEMDTMRQ---ELDE----AKNLVEV 166
                |.|.|:|.:|:|.:.||..:|.||..||..:...:||:.::|:   :|.|    .::|..|
Mouse   169 LPPPPTEQYWKEVADQNQRALGTALIENNQLHVTLTQKQEEIASLRERNVQLKELASRTRHLASV 233

  Fly   167 LKEI 170
            |.::
Mouse   234 LDKL 237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gemininNP_001260727.1 Geminin 25..188 CDD:284760 34/134 (25%)
McidasNP_001033003.1 Necessary and sufficient for its degradation during the cell cycle. /evidence=ECO:0000250 1..129 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..71
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 88..107 1/2 (50%)
Necessary and sufficient for proper nuclear localization. /evidence=ECO:0000250 130..379 28/108 (26%)
Necessary and sufficient for interaction with GMNN and sufficient for homodimerization. /evidence=ECO:0000250 171..241 21/67 (31%)
Geminin <173..237 CDD:284760 21/63 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 291..312
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834816
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2C45P
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13372
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.890

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