DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment geminin and GMNN

DIOPT Version :9

Sequence 1:	NP_001260727.1	Gene:	geminin / 35563	FlyBaseID:	FBgn0033081	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_001238918.1	Gene:	GMNN / 51053	HGNCID:	17493	Length:	209	Species:	Homo sapiens

Alignment Length:	204	Identity:	56/204 - (27%)
Similarity:	89/204 - (43%)	Gaps:	50/204 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ETEAEQKEHLKQQ---RQTLKPLQGNVNDKENLTGSGRASIVDQLSRLKAGVQVAPKYGKRKCVD 74
            :.:.|.||::|..   |:|||.:|          .|...|:|.:.:.|.||:      .|||
Human     7 QKQEEIKENIKNSSVPRRTLKMIQ----------PSASGSLVGRENELSAGL------SKRK--- 52

  Fly    75 TAPAISTKDADTQTDAE---AVPLGNADK---PITAE--DLTSTAEPGENYYKLLAEQRRLALED 131
                 ...|..|.|.:.   .||..:.:|   .:|.|  ||.....|...|:|.:||:||.||.:
Human    53 -----HRNDHLTSTTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWKEVAEKRRKALYE 112

  Fly   132 SLTENRHLHERIEGLEEEMDTMR---QELDEAKNLVEVLKEICEE------------DNSEVEED 181
            :|.||..||:.||..:.|:..::   :||.|....|:.:.|:.|.            ||.|.:.:
Human   113 ALKENEKLHKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFDSE 177

  Fly   182 DTTGDEDKV 190
            :.|.::..|
Human   178 EETVEDSLV 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
geminin	NP_001260727.1	Geminin	25..188	CDD:284760	51/188 (27%)
GMNN	NP_001238918.1	Geminin	1..184	CDD:399999	55/200 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79		24/95 (25%)
		Necessary and sufficient for interaction with IDAS and CDT1. /evidence=ECO:0000269\|PubMed:21543332	82..161		27/78 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..209		5/23 (22%)
		Homeodomain binding	170..190		5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C45P
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I5479
Isobase	1	0.950	-	0	Normalized mean entropy	S7949
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1631696at2759
OrthoFinder	1	1.000	-	-		FOG0009565
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.840