DRSC/TRiP Functional Genomics Resources

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Protein Alignment geminin and MCIDAS

DIOPT Version :10

Sequence 1:NP_610218.1 Gene:geminin / 35563 FlyBaseID:FBgn0033081 Length:192 Species:Drosophila melanogaster
Sequence 2:NP_001177716.1 Gene:MCIDAS / 345643 HGNCID:40050 Length:385 Species:Homo sapiens


Alignment Length:87 Identity:25/87 - (28%)
Similarity:40/87 - (45%) Gaps:18/87 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 EAVPLGNADKPITAEDLTSTAEPGENYYKLLAEQRRLALEDSLTENRHLH-------ERIEGLEE 148
            ::.||...|.|           |.|.|:|.:|:|.:.||.|:|.||..||       |.|..|:|
Human   166 QSPPLRPPDVP-----------PPEQYWKEVADQNQRALGDALVENNQLHVTLTQKQEEIASLKE 219

  Fly   149 EMDTMRQELDEAKNLVEVLKEI 170
            ....:::.....::|..||.::
Human   220 RNVQLKELASRTRHLASVLDKL 241

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gemininNP_610218.1 Geminin 25..>165 CDD:462159 23/80 (29%)
geminin_CC 115..179 CDD:439143 20/63 (32%)
MCIDASNP_001177716.1 Necessary and sufficient for its degradation during the cell cycle 1..130
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 86..111
Necessary and sufficient for proper nuclear localization 131..385 25/87 (29%)
Necessary and sufficient for interaction with GMNN and sufficient for homodimerization. /evidence=ECO:0000269|PubMed:21543332 173..245 23/80 (29%)
McIdas_CC 182..245 CDD:439144 18/60 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..319
Blue background indicates that the domain is not in the aligned region.

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