DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-2 and FMO1

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_012046.4	Gene:	FMO1 / 856581	SGDID:	S000001219	Length:	432	Species:	Saccharomyces cerevisiae

Alignment Length:	442	Identity:	111/442 - (25%)
Similarity:	197/442 - (44%)	Gaps:	62/442 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DKRRVCVIGAGTAGLCALK---NSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEG 68
            ||:|:.:||.|..||.|.:   .|| ...:...:.:..:|||.|.:.|:......      ||:.
Yeast     5 DKKRLAIIGGGPGGLAAARVFSQSL-PNFEIEIFVKDYDIGGVWHYPEQKSDGRV------MYDH 62

  Fly    69 LRTNLPKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHF---KLKAHIKLQHEVIRVRPRLD 130
            |.||:.|::|.:..:.:.::: ..:.:...:.|:|::|.:.|   |....|....||..::.:..
Yeast    63 LETNISKKLMQFSGFPFEENV-PLYPSRRNIWEYLKAYYKTFIANKDAISIHFSTEVTYLKKKNS 126

  Fly   131 DWEVYVWDHSTDTCDPVYYDFVYVCNGHYTEPDLP-EVEGLDLFEGNK--MHSHLYRKADKFKDA 192
            .||:...|....|...  :|||.|.:|||:.|.|| .:.||||:..||  .||..::..:..::.
Yeast   127 QWEITSKDELRTTKSD--FDFVIVASGHYSVPKLPTNIAGLDLWFDNKGAFHSKDFKNCEFAREK 189

  Fly   193 RVLIIGAGPSGMDITNHVRLAAKQVFLS-HHLSTTPNTAFMGNVTQKPDVKRFTKDGAVFTDGST 256
            .|:::|.|.||.||.|.:...||:|:.| ...::....|.:....|..|...:.......:||..
Yeast   190 VVIVVGNGSSGQDIANQLTTVAKKVYNSIKEPASNQLKAKLIETVQTIDSADWKNRSVTLSDGRV 254

  Fly   257 -ESFDHVMFCTGYKYTFPCLSTDVGVQVIDNFV----------QPLWKHCININHPTMAFVGLPF 310
             ::.|:::|.|||.|:||.:...|.::|:...|          ..||:|.|.:..||::|:..|.
Yeast   255 LQNIDYIIFATGYYYSFPFIEPSVRLEVLGEGVTGDKHSSVNLHNLWEHMIYVKDPTLSFILTPQ 319

  Fly   311 NVIPTHIFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVRNQKKAHQMGERQFVYYN 375
            .|||..:.::|....::.|.  :..|......::         .||..|..|.     :...||.
Yeast   320 LVIPFPLSELQAAIMVEVFC--KSLPITTTFDSN---------ACGTHNFPKG-----KDLEYYA 368

  Fly   376 ELASIAG-----IENIKPVIHKLMKDCGKKYIFELDTYRSNKYTILDDENFL 422
            ||..:..     :.:.:||:          :...|...|::.||..::.|.|
Yeast   369 ELQELLNSIPRRVGHFEPVV----------WDDRLIDLRNSSYTDKEERNVL 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	58/210 (28%)
FMO1	NP_012046.4	CzcO	23..360	CDD:224983	89/357 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I1679
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I1220
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		otm46638
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	1	1.100	-	-	O	PTHR43539
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2115
SonicParanoid	1	1.000	-	-		X69
TreeFam	1	0.960	-	-
	12	11.860