DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-2 and Fmo3

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_445885.2	Gene:	Fmo3 / 84493	RGDID:	619761	Length:	531	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	143/478 - (29%)
Similarity:	218/478 - (45%)	Gaps:	114/478 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KRRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTN 72
            ||:|.|||||.:||.|:::.||.||:...:||..::||.|.||     |..:|..:|:|:.:.||
  Rat     2 KRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFS-----DHTEEGRASIYQSVFTN 61

  Fly    73 LPKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLD-----DW 132
            ..||:|.:||:.||||. .:|:.::::.|::.|:|....|..:|:.:..|.|:....|     .|
  Rat    62 SSKEMMCFPDFPYPDDF-PNFMHNSKLQEYITSFATEKNLLKYIQFETLVTRINKCPDFSTTGKW 125

  Fly   133 EVYVWDHSTDTCDPVYYDFVYVCNGHYTEPDLPE--VEGLDLFEGNKMHSHLYRKADKFKDARVL 195
            ||....:|..  :...:|.|.:|:||:..|.||:  ..||:.|:|...||..|::...:|..|||
  Rat   126 EVTTEKNSKK--ETAVFDAVMICSGHHVYPHLPKDSFPGLNRFKGKCFHSRDYKEPGTWKGKRVL 188

  Fly   196 IIGAGPSGMDITNHVRLAAKQV-------------------------------FLSHHLSTT--- 226
            :||.|.||.||...:...|:||                               ||.::|.|.
  Rat   189 VIGLGNSGCDIAAELSHVAQQVIISSRSGSWVMSRVWNDGYPWDMVVITRFQTFLKNNLPTAISD 253

  Fly   227 -----------------------------------PNTAFMGNVTQKPDVKRFTKDGAVFTDGST 256
                                               |.....|.|:.||:||.||:..|||.||:.
  Rat   254 WWYMKQMNARFKHENYGLMPLNGTLRKEPVFNDELPARILCGTVSIKPNVKEFTETSAVFEDGTV 318

  Fly   257 -ESFDHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCI--NINHPTMAFVGLPFNV---IPT 315
             |..|.|:|.|||.|.:|.|...: ::..:|.| .|:|...  .:..||||.:||..::   |||
  Rat   319 FEGIDCVIFATGYGYAYPFLDDSI-IKSRNNEV-TLYKGIFPPQLEKPTMAVIGLVQSLGAAIPT 381

  Fly   316 HIFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVRNQKKAHQMGER------QFVYY 374
              .|:|.|:..:...|....||...|:.|:::::|          ||....|..      ..||.
  Rat   382 --TDLQARWAAQVIRGTCILPSVNDMMDDIDEKMG----------KKLKWFGNSTTIQTDYIVYM 434

  Fly   375 NELASIAGIENIKP-VIHKLMKD 396
            :||||..|   .|| ::...:||
  Rat   435 DELASFIG---AKPNILWLFLKD 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	73/208 (35%)
Fmo3	NP_445885.2	FMO-like	2..530	CDD:395602	143/478 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3468
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm9017
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.780