DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-2 and si:dkey-239i20.4

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001038299.2	Gene:	si:dkey-239i20.4 / 557628	ZFINID:	ZDB-GENE-030131-2644	Length:	543	Species:	Danio rerio

Alignment Length:	464	Identity:	140/464 - (30%)
Similarity:	198/464 - (42%)	Gaps:	116/464 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTNL 73
            :||.|||||::||.|:|..|:.||:.|.:|...:|||.|.|.|   |.|.|  ..|:|..|..|.
Zfish     3 KRVAVIGAGSSGLAAIKCCLDEGLEPVCFESSDDIGGLWRFRE---KPETD--RCSIYHSLTVNT 62

  Fly    74 PKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLD-----DWE 133
            .||:|.|.|:..||:. .:|:.::.::::.|.|||||.|...|..|..|..||.|.|     .||
Zfish    63 SKEMMCYSDFPVPDNF-PNFMHNSLIVQYYRLYAEHFNLFERIHFQTTVRSVRQRPDFSVSGQWE 126

  Fly   134 VYVWDHSTDTCDPVYYDFVYVCNGHYTEP--DLPEVEGLDLFEGNKMHSHLYRKADKFKDARVLI 196
            |...|..... :...:|.|.||.||||:|  .|.|..|:|.|.|..:||..|:|.|::...:|||
Zfish   127 VVTADRDGQV-ETHMFDGVLVCVGHYTQPIKPLSEFPGIDTFPGTVIHSWEYKKPDQYIGKKVLI 190

  Fly   197 IGAGPSGMDITNHVRLAAKQVFLS----------------------------------------- 220
            ||.|.||.||...:....::.|||
Zfish   191 IGIGNSGGDIAVELSRTCEKTFLSTRKGSWVIGRMVEKGLPLDMMNISRVQDLMHCLIPRALVNW 255

  Fly   221 -----------HHL-----------------STTPNTAFMGNVTQKPDVKRFTKDGAVFTDGS-T 256
                       |.|                 ...|....:|.:..||:|:.|.....||.||| .
Zfish   256 IGERSLNQRHDHKLYGLQPKHRILDHRPVINDDLPGRILVGELVLKPNVQTFHGSTVVFDDGSIE 320

  Fly   257 ESFDHVMFCTGYKYTFPCL------STDVGVQVIDNFVQPLWKHCININHPTMAFVGL-----PF 310
            |..|.|:.||||.|.||.|      |.|.|:::......|      ::..||:|.:||     |
Zfish   321 EKIDAVILCTGYDYKFPFLPDSLNSSADGGMKLYRRIFPP------SLERPTLAIIGLLQTRGP- 378

  Fly   311 NVIPTHIFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVRNQKKAH---QMGERQFV 372
             ::|.  .::|.|:..:...|....||.|:|...:|::|        :...|:|   ::...|..
Zfish   379 -IMPA--AELQARWATRVIKGLNHLPSAEKMSKRIEKDI--------KPYLKSHPCPKLASLQVD 432

  Fly   373 YYNELASIA 381
            |...|.|||
Zfish   433 YIPYLDSIA 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	83/208 (40%)
si:dkey-239i20.4	NP_001038299.2	FMO-like	3..530	CDD:109787	140/464 (30%)
si:dkey-239i20.4	NP_001038299.2	NADB_Rossmann	6..206	CDD:304358	83/206 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H101040
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.730