DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-2 and SPBP16F5.08c

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_595782.1	Gene:	SPBP16F5.08c / 2541228	PomBaseID:	SPBP16F5.08c	Length:	447	Species:	Schizosaccharomyces pombe

Alignment Length:	460	Identity:	123/460 - (26%)
Similarity:	199/460 - (43%)	Gaps:	99/460 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRVCVIGAGTAGLCALKNSL-EAGLDAVA-YERGTEIGGTWIF----SEEMPKDEYDEV------ 61
            |::.:||||.:||...|..| |...|.|. :||....||.|.:    |.::|....:.:
pombe     7 RKIAIIGAGPSGLVTAKALLAEKAFDQVTLFERRGSPGGVWNYTSTLSNKLPVPSTNPILTTEPI 71

  Fly    62 ---------HSSMYEGLRTNLPKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIK 117
                     .|.:|..|:||.|.|:|||.|.|:... |..|...:.:.|:.|.||:  .|...||
pombe    72 VGPAALPVYPSPLYRDLQTNTPIELMGYCDQSFKPQ-TLQFPHRHTIQEYQRIYAQ--PLLPFIK 133

  Fly   118 LQHEVIRVRPRLDDWEVYVWDHSTDTCDPV---YYDFVYVCNGHYTEPDLPEVEGLDLF----EG 175
            |..:|:.:..:...|.|..  ..|....|:   .:|.|.:|||||..|.:|.::|||.:    .|
pombe   134 LATDVLDIEKKDGSWVVTY--KGTKAGSPISKDIFDAVSICNGHYEVPYIPNIKGLDEYAKAVPG 196

  Fly   176 NKMHSHLYRKADKFKDARVLIIGAGPSGMDITNHVRLAAKQVFLSHHLSTTPNTAFMG------- 233
            :.:||.|:|:.:.|....||::|...|..|:..|:...||.....         :.:|
pombe   197 SVLHSSLFREPELFVGESVLVVGGASSANDLVRHLTPVAKHPIYQ---------SLLGGGDIQNE 252

  Fly   234 NVTQKPDVKRF--------TKDGAVFTDGSTESFDHVMFCTGYKYT--FPCLS--TDVGVQVID- 285
            ::.|.|::.:|        .|.|.|.:     :.|.|::||||.|:  ||.|:  .....::||
pombe   253 SLQQVPEITKFDPTTREIYLKGGKVLS-----NIDRVIYCTGYLYSVPFPSLAKLKSPETKLIDD 312

  Fly   286 -NFVQPLWKHCININHPTMAFVGLPFNVIPTHIFDMQVRFTLKFFTGQRKFPSREQMIADLEQEI 349
             :.|..:::|...|..||:|||||..:|:|......|..|..:.::|:.|.||:|:.:
pombe   313 GSHVHNVYQHIFYIPDPTLAFVGLALHVVPFPTSQAQAAFLARVWSGRLKLPSKEEQL------- 370

  Fly   350 GERWGCGVRNQKKAHQMGERQFVYYNELASIAGIENIKPVIHKLMKDCGKKYIFELDTYRSNKYT 414
              :|            ..|..|       |::|..|   :.|.|.......||.:|..:......
pombe   371 --KW------------QDELMF-------SLSGANN---MYHSLDYPKDATYINKLHDWCKQATP 411

  Fly   415 ILDDE 419
            :|::|
pombe   412 VLEEE 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	69/229 (30%)
SPBP16F5.08c	NP_595782.1	CzcO	1..447	CDD:224983	123/460 (27%)
SPBP16F5.08c	NP_595782.1	NAD_binding_9	11..175	CDD:290190	49/168 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	1.000	Domainoid score	I2275
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1383
OMA	1	1.010	-	-		QHG55225
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		otm47097
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2115
SonicParanoid	1	1.000	-	-		X69
TreeFam	1	0.960	-	-
	11	10.760