DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-2 and Fmo1

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_036924.1	Gene:	Fmo1 / 25256	RGDID:	2622	Length:	532	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	129/482 - (26%)
Similarity:	203/482 - (42%)	Gaps:	127/482 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTNL 73
            :||.::|||.:||.::|..||.||:...:||..::||.|.|:|.:     :|..:|:|..:.:|.
  Rat     3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSCDLGGLWRFTEHV-----EEGRASLYNSVVSNS 62

  Fly    74 PKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLD-----DWE 133
            .||:..|.|:.:|:|. .:|:.::..||:|:.||..|.|...|....:|..:..|.|     .||
  Rat    63 SKEMSCYSDFPFPEDY-PNFVPNSLFLEYLQLYATQFNLLRCIYFNTKVCSITKRPDFAVSGQWE 126

  Fly   134 VYV---WDHSTDTCDPVYYDFVYVCNGHYTEPDLP--EVEGLDLFEGNKMHSHLYRKADKFKDAR 193
            |..   ...|:||     :..|.||.|..|.|.||  ...|:..|:|...||..|:..|.|||.|
  Rat   127 VVTVCQGKQSSDT-----FAAVMVCTGFLTNPHLPLDSFPGIQTFKGQYFHSRQYKHPDVFKDKR 186

  Fly   194 VLIIGAGPSGMDITNHVRLAAKQVFLS------------------------------HHLSTTPN 228
            ||::|.|.||.||.......||:||||                              .:|..||.
  Rat   187 VLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMIFMTRFQNMLRNLLPTPV 251

  Fly   229 TAFM---------------------------------------GNVTQKPDVKRFTKDGAVFTD- 253
            .:::                                       |.|..||.:|...::..||.:
  Rat   252 VSWLISKKMNSWFNHVNYGVAPEDRTQLREPVLNDELPGRIITGKVLIKPSIKEVKENSVVFNNT 316

  Fly   254 GSTESFDHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCI--NINHPTMAFVGL--PF-NVI 313
            ...|..|.::|.|||.:.||.|  |..:..:::....|:|:..  ::..||:|.:||  |. ::|
  Rat   317 PKEEPIDVIVFATGYSFAFPFL--DESIVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMI 379

  Fly   314 PTHIFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVRNQKKAHQMG---------ER 369
            ||.  :.|.|:.::...|....|....|:    :|:.||        ||....|         :.
  Rat   380 PTG--ETQARWVVQVLKGATTLPPPSVMM----KEVNER--------KKNKHSGFGLCYCKALQS 430

  Fly   370 QFVYYNE--LASIAGIENIKPVIHKLM 394
            .::.|.:  |.||    |.||.:..::
  Rat   431 DYITYIDDLLTSI----NAKPDLRAML 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	72/211 (34%)
Fmo1	NP_036924.1	FMO-like	3..532	CDD:109787	129/482 (27%)
		NADB_Rossmann	7..148	CDD:304358	48/151 (32%)
		NADB_Rossmann	<81..>342	CDD:304358	71/267 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3468
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm9017
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.780