DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-2 and Fmo5

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_653340.2	Gene:	Fmo5 / 246248	RGDID:	628602	Length:	533	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	140/465 - (30%)
Similarity:	217/465 - (46%)	Gaps:	104/465 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KRRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTN 72
            |:|:.|||:|.:||..:|..||.||:.|.:|...:|||.|.:.|..     :|..:|:|:.:..|
  Rat     3 KKRIAVIGSGASGLTCIKCCLEEGLEPVCFEMSDDIGGLWRYQENP-----EEGRASIYKSVIIN 62

  Fly    73 LPKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLD-----DW 132
            ..||:|.:.||..||.. .:|:.::||||:.|.||:.|.|..:|:.:..|..|:.:.|     .|
  Rat    63 TSKEMMCFSDYPIPDHY-PNFMHNSQVLEYFRMYAKEFGLLKYIQFKTTVCSVKKQPDFSTSGQW 126

  Fly   133 EVYVWDHSTDTCDPVYYDFVYVCNGHYTEPDLP--EVEGLDLFEGNKMHSHLYRKADKFKDARVL 195
            :|.......:..|  .:|.|.||.||:|:|.||  ...|::.|:|...||..|:...:|...||:
  Rat   127 QVVTEHEGKEQVD--VFDGVLVCTGHHTDPHLPLDSFPGIEKFKGKYFHSREYKNPVEFTGKRVI 189

  Fly   196 IIGAGPSGMDITNHVRLAAKQVFLS---------------------------HHLS--------- 224
            :||.|.||.|:...:...|||||||                           ::||
  Rat   190 VIGIGNSGGDLAVEISHTAKQVFLSTRRGAWILNRVGKHGYPIDILLSSRITNYLSKICGSALKN 254

  Fly   225 ---------------------------------TTPNTAFMGNVTQKPDVKRFTKDGAVFTDGST 256
                                             ..||....|.|..|.:||.||:..|:|.|||.
  Rat   255 RYMEKQLNQRFDHEMFGLKPKHSALGQHPTINDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSR 319

  Fly   257 E-SFDHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCI--NINHPTMAFVGL--PFNVIPTH 316
            | ..|.|:|.|||.:.||.|  :..|:|:.|.|. |:|...  |:..||:|.:||  |...| ..
  Rat   320 EDDIDVVIFATGYSFAFPFL--EDSVKVVQNKVS-LYKKVFPPNLEKPTLAIIGLIQPLGAI-MP 380

  Fly   317 IFDMQVRFTLKFFTGQRKFPSREQMIADL---EQEIGERWGCGVRNQKKAHQMGERQFVYYNELA 378
            |.::|.|:..:.|.|.:|.||:.:|:|::   .:|:.:|:   |.:|:...| |:    |.:.:.
  Rat   381 ISELQGRWATQVFKGLKKLPSQSEMMAEINKTREEMAKRY---VDSQRHTIQ-GD----YIDTME 437

  Fly   379 SIAGIENIKP 388
            .||.:..::|
  Rat   438 EIADLVGVRP 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	71/208 (34%)
Fmo5	NP_653340.2	FMO-like	3..532	CDD:395602	140/465 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3468
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm9017
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.780