Protein Alignment Fmo-2 and FMO4

DIOPT Version :9

• Sequence 1: NP_610217.1
• Gene: Fmo-2 / 35561
• FlyBaseID: FBgn0033079
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_002013.1
• Gene: FMO4 / 2329
• HGNCID: 3772
• Length: 558
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 132/479 - (27%)
• Similarity: 201/479 - (41%)
• Gaps: 118/479 - (24%)

  Fly     9 RRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTNL 73
            ::|.|||||.:||.::|..::..|:...:||..:|||.|.|:|. .||....|    |:.|.||:
Human     3 KKVAVIGAGVSGLSSIKCCVDEDLEPTCFERSDDIGGLWKFTES-SKDGMTRV----YKSLVTNV 62

  Fly    74 PKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLDDWEVYVWD 138
            .||:..|.|:.:.:|. .:|:...:..::|:.:||||.|..:|:.:..|..:..|.|..|...||
Human    63 CKEMSCYSDFPFHEDY-PNFMNHEKFWDYLQEFAEHFDLLKYIQFKTTVCSITKRPDFSETGQWD 126

  Fly   139 HSTDT---CDPVYYDFVYVCNGHYTEPDLP--EVEGLDLFEGNKMHSHLYRKADKFKDARVLIIG 198
            ..|:|   .:...:|.|.||.||:..|.||  ...|:..|:|..:||..|:..:.|:..|||:||
Human   127 VVTETEGKQNRAVFDAVMVCTGHFLNPHLPLEAFPGIHKFKGQILHSQEYKIPEGFQGKRVLVIG 191

  Fly   199 AGPSGMDITNHVRLAAKQVFLS------------------------------------------- 220
            .|.:|.||...:...|.||.||
Human   192 LGNTGGDIAVELSRTAAQVLLSTRTGTWVLGRSSDWGYPYNMMVTRRCCSFIAQVLPSRFLNWIQ 256

  Fly   221 ------------HHLSTT-------------PNTAFMGNVTQKPDVKRFTKDGAVFTDGST-ESF 259
                        :.||.|             ||....|.:|.|..|..||:..|||.||:. |:.
Human   257 ERKLNKRFNHEDYGLSITKGKKAKFIVNDELPNCILCGAITMKTSVIEFTETSAVFEDGTVEENI 321

  Fly   260 DHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHC------------ININHPTMA---FVGLP 309
            |.|:|.|||.::||.            |.:||...|            :|:...|:|   .:||.
Human   322 DVVIFTTGYTFSFPF------------FEEPLKSLCTKKIFLYKQVFPLNLERATLAIIGLIGLK 374

  Fly   310 FNVIPTHIFDMQVRFTLKFFTGQRKF-PSREQMIADLEQEIGERWGCGVRNQKKAHQMGERQFVY 373
            .:::..  .::|.|:..:.|.|..|. ||::.|:...|:|...:.|......|.       :|.|
Human   375 GSILSG--TELQARWVTRVFKGLCKIPPSQKLMMEATEKEQLIKRGVFKDTSKD-------KFDY 430

  Fly   374 YNELASIAGIENIKPVIHKL-MKD 396
            ...:..||.....||.|..| :||
Human   431 IAYMDDIAACIGTKPSIPLLFLKD 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	70/206 (34%)
FMO4	NP_002013.1	FMO-like	2..532	CDD:109787	132/479 (28%)
		NAD_binding_8	7..>41	CDD:290186	14/33 (42%)
		NADB_Rossmann	<89..220	CDD:304358	45/130 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3793
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8542
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780