DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-2 and FMO3

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001002294.1	Gene:	FMO3 / 2328	HGNCID:	3771	Length:	532	Species:	Homo sapiens

Alignment Length:	472	Identity:	126/472 - (26%)
Similarity:	210/472 - (44%)	Gaps:	117/472 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTNL 73
            ::|.:||||.:||.::::.||.||:...:|:..:|||.|.||     |..:|..:|:|:.:.:|.
Human     3 KKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFS-----DHAEEGRASIYKSVFSNS 62

  Fly    74 PKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLDDWEVYVWD 138
            .||:|.:||:.:|||. .:|:.::::.|::.::|:...|..:|:.:..|..|....|......||
Human    63 SKEMMCFPDFPFPDDF-PNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWD 126

  Fly   139 HSTD---TCDPVYYDFVYVCNGHYTEPDLPE--VEGLDLFEGNKMHSHLYRKADKFKDARVLIIG 198
            .:|:   ..:...:|.|.||:||:..|:||:  ..||:.|:|...||..|::...|...|||::|
Human   127 VTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVG 191

  Fly   199 AGPSGMDITNHVRLAAKQV-------------------------------FLSHHLSTT------ 226
            .|.||.||...:...|:||                               ||.::|.|.
Human   192 LGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGTFLKNNLPTAISDWLY 256

  Fly   227 --------------------------------PNTAFMGNVTQKPDVKRFTKDGAVFTDGST-ES 258
                                            |.:...|.|:.||:||.||:..|:|.||:. |.
Human   257 VKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEG 321

  Fly   259 FDHVMFCTGYKYTFPCLSTDV------GVQVIDNFVQPLWKHCININHPTMAFVGLPFNV---IP 314
            .|.|:|.|||.:.:|.|...:      .:.:......||      :...|:|.:|...::   ||
Human   322 IDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPL------LEKSTIAVIGFVQSLGAAIP 380

  Fly   315 THIFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVRNQKKAHQMGERQ------FVY 373
            |  .|:|.|:..:...|....||.|.|:.|:.:::          :||....|:.:      .||
Human   381 T--VDLQSRWAAQVIKGTCTLPSMEDMMNDINEKM----------EKKRKWFGKSETIQTDYIVY 433

  Fly   374 YNELASIAGIENIKPVI 390
            .:||:|..|   .||.|
Human   434 MDELSSFIG---AKPNI 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	67/206 (33%)
FMO3	NP_001002294.1	FMO-like	2..532	CDD:109787	126/472 (27%)
FMO3	NP_001002294.1	NAD_binding_8	7..>41	CDD:290186	14/33 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3793
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8542
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780