Protein Alignment Fmo-2 and FMO2

DIOPT Version :9

• Sequence 1: NP_610217.1
• Gene: Fmo-2 / 35561
• FlyBaseID: FBgn0033079
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_001451.2
• Gene: FMO2 / 2327
• HGNCID: 3770
• Length: 535
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 133/479 - (27%)
• Similarity: 214/479 - (44%)
• Gaps: 116/479 - (24%)

  Fly     9 RRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTNL 73
            ::|.|||||.:||.:||..::.||:...:||..:|||.|.|     |:..::..:|:|:.:.||.
Human     3 KKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRF-----KENVEDGRASIYQSVVTNT 62

  Fly    74 PKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLD-----DWE 133
            .||:..:.|:..|:|. .:|:.::::||:.|.:|:.|.|..:|:.|..|:.||...|     .|:
Human    63 SKEMSCFSDFPMPEDF-PNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFSSSGQWK 126

  Fly   134 VYVWDHSTDTCDPVYYDFVYVCNGHYTEPDLP--EVEGLDLFEGNKMHSHLYRKADKFKDARVLI 196
            |....:..:  ....:|.|.||:||:..|.:|  ...|::.|:|...||..|:..|.|:..|:|:
Human   127 VVTQSNGKE--QSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPDGFEGKRILV 189

  Fly   197 IGAGPSGMDITNHVRLAAKQVFLSHHLST------------------------------------ 225
            ||.|.||.||...:...|.|||:|....|
Human   190 IGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKW 254

  Fly   226 ---------------------------------TPNTAFMGNVTQKPDVKRFTKDGAVFTDGST- 256
                                             .|:....|.:..|..||..|:..|:|.||:.
Human   255 MIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVE 319

  Fly   257 ESFDHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCI--NINHPTMAFVGL--PF-NVIPTH 316
            |:.|.::|.|||.::||.|. |..|:|.:|.|. |:|:..  :::..|:|.:||  |. ::.||
Human   320 ENIDVIIFATGYSFSFPFLE-DSLVKVENNMVS-LYKYIFPAHLDKSTLACIGLIQPLGSIFPT- 381

  Fly   317 IFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVRNQKKAHQMGERQ-------FV-Y 373
             .::|.|:..:.|.|....||...|:.|:.:          ||:|:....||.|       :| |
Human   382 -AELQARWVTRVFKGLCSLPSERTMMMDIIK----------RNEKRIDLFGESQSQTLQTNYVDY 435

  Fly   374 YNELASIAGIENIKPVIHKLM-KD 396
            .:|||...|   .||....|: ||
Human   436 LDELALEIG---AKPDFCSLLFKD 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	68/208 (33%)
FMO2	NP_001451.2	FMO-like	2..532	CDD:109787	133/479 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3793
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8542
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2115
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.810