DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-2 and Gm4847

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001157784.1	Gene:	Gm4847 / 226604	MGIID:	3643320	Length:	537	Species:	Mus musculus

Alignment Length:	480	Identity:	154/480 - (32%)
Similarity:	231/480 - (48%)	Gaps:	107/480 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTNL 73
            :|:.|||||.:||.|:|..||.||:...:|:.::|||.|.: ||:||..    :..:|:.|..|.
Mouse     4 KRIAVIGAGVSGLGAIKCCLEEGLEPTCFEKKSDIGGLWKY-EEIPKSG----NLGIYKSLTCNT 63

  Fly    74 PKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLD-----DWE 133
            .||:..:.||..||.. .:::..::::|:||.||.||.|..||:.|..|..::.|.|     .|:
Mouse    64 SKEMTAFSDYPIPDHY-PNYMHHSKMMEYLRMYARHFGLMKHIQFQTNVCNIKKRPDFSSSGQWD 127

  Fly   134 VYVWDHSTDTCDPVY-YDFVYVCNGHYTEPDLP--EVEGLDLFEGNKMHSHLYRKADKFKDARVL 195
            |.|   .|:.....| :|.:.||:|||||...|  :.||:..|:|:.:|:..|:..|.|...||.
Mouse   128 VVV---ETEEMQKTYIFDGIMVCSGHYTEKYFPLQDFEGISKFQGSYLHTWEYKHPDNFVGKRVA 189

  Fly   196 IIGAGPSGMDITNHVRLAAKQVFLS---------------HHLSTT------------------- 226
            :||.|.||.|:...:...|.|||||               ..:.||
Mouse   190 VIGLGNSGADVAGEISRVADQVFLSTRQGAWIWNRVWDHGEPMDTTVFTRYNRAVQKICPRYIIN 254

  Fly   227 -----------------------------------PNTAFMGNVTQKPDVKRFTKDGAVFTDGST 256
                                               ||...:|.|..||:||.||...|:|.||:.
Mouse   255 RQMEKKLNGRFNHANYGLLPTHRILEQRTVLSDDLPNRIIIGKVKIKPNVKEFTSTSAIFEDGTK 319

  Fly   257 ESFDHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCI--NINHPTMAFVGL--PFN-VIPTH 316
            |:.|.|:|.||||.:||.||.|.|  |:|| ...::|:..  .:..||:||:|:  |.. ::||.
Mouse   320 ENIDVVIFATGYKLSFPFLSDDSG--VLDN-QYSMFKYVFPPELEKPTLAFIGILQPAGAILPTS 381

  Fly   317 IFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVRNQKKAHQMGER-QFV-YYNELAS 379
              ::|.|:.:..|.|.:|.|||..||||:.::..:....|   .||..|...| .|| |.:|:||
Mouse   382 --ELQSRWVVHVFKGIKKLPSRRAMIADINRKNHQIMAKG---SKKILQDHRRVTFVDYMDEIAS 441

  Fly   380 IAGIE-NIKPVI---HKLMKD--CG 398
            ..|:: |:..::   .||.|:  ||
Mouse   442 EIGVKPNLLSLLLWDTKLAKEVFCG 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	75/209 (36%)
Gm4847	NP_001157784.1	FMO-like	4..516	CDD:109787	154/480 (32%)
Gm4847	NP_001157784.1	NAD_binding_8	8..>48	CDD:290186	20/40 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H101040
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3710
Isobase	1	0.950	-	0	Normalized mean entropy	S2746
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8771
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2115
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.690