DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fmo-2 and fmo-4

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001256532.1	Gene:	fmo-4 / 179845	WormBaseID:	WBGene00001479	Length:	568	Species:	Caenorhabditis elegans

Alignment Length:	490	Identity:	124/490 - (25%)
Similarity:	204/490 - (41%)	Gaps:	124/490 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTNLP 74
            ||||:|||.:||.|:|..:|.|||.|.:|:..:|||.|.:     :....::..::.|....|..
Worm     2 RVCVVGAGASGLPAIKACIEEGLDVVCFEKTADIGGLWNY-----RPGQKDIGGTVMESTVVNTS 61

  Fly    75 KEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRV-RPRLDDWEVYVWD 138
            ||:|.|.|:..|.:.. :|:...:|:|:::||||||.|...|:....|.|: |...:.:.|.:.:
Worm    62 KEMMAYSDFPPPAEFA-NFMHHTKVIEYIKSYAEHFGLMDKIRFNTPVKRISRNEQNKYIVSLQN 125

  Fly   139 HSTDTCDPVYYDFVYVCNGHYTEPDLPEVEGLDLFEGNKMHSHLYRKADKFKDARVLIIGAGPSG 203
            ...:.     ::.:.:|.||:.||..||::.||.|:|..:|::.|.....::...|.::|.|.|.
Worm   126 GEIEE-----FEKLILCTGHHAEPSYPELKNLDNFKGKVVHAYDYTNTSGYEGKDVFLLGIGNSA 185

  Fly   204 MDITNHVRLAAKQVFLSHH----------------------------LSTTPNTA---FM----- 232
            :||...:...||.|.:|..                            |.|.|:..   ||
Worm   186 LDIAVDIAKIAKSVTISTRRGTWIFNRVSQGGMPYDVQLFSRYYDTLLKTIPHAVANDFMEYRLQ 250

  Fly   233 ---------------------------------GNVTQKPDVKRFTKDGAVFTDGSTESFDHVMF 264
                                             |.:|...|:..||::..:...|.....|..:.
Worm   251 QRMDHDVYGLRPDHRFFQQHPTVNDALANLLCAGYITITEDIDTFTENSVIVKGGREFKCDIFLT 315

  Fly   265 CTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCININHPTMAFVGL--PFNVIPTHIFDMQVRFTLK 327
            ||||.:.||.:.:|: |: |.|...||:|:....|..::|.:||  |...| ..|.::|.|:..:
Worm   316 CTGYTFGFPFVDSDI-VE-IKNQQVPLYKYVFPPNSDSVAVIGLIQPIGSI-APISEIQSRWAAR 377

  Fly   328 FFTGQRKFPSREQMIADLEQEIGERWGCGVRNQKKAHQMGERQF------------VYYNELASI 380
            .|.|:.:.||.::.|.|:              |||...|.:|.|            .|.:|:|.|
Worm   378 VFAGRCQLPSSQEQIDDI--------------QKKKAAMKKRYFDSIKHTIQVDYMSYMDEIAEI 428

  Fly   381 AGIENIKPVIH----------KLMKDCGKKYIFEL 405
            .|.  :.|:.|          ||.......|.:.|
Worm   429 IGC--LPPMKHYLFFYPRFWMKLFMGANVPYAYRL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	61/202 (30%)
fmo-4	NP_001256532.1	FMO-like	2..488	CDD:109787	124/490 (25%)
fmo-4	NP_001256532.1	NADB_Rossmann	4..209	CDD:304358	65/215 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830