DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fmo-2 and Fmo1

DIOPT Version :9

Sequence 1:	NP_610217.1	Gene:	Fmo-2 / 35561	FlyBaseID:	FBgn0033079	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001317220.1	Gene:	Fmo1 / 14261	MGIID:	1310002	Length:	532	Species:	Mus musculus

Alignment Length:	479	Identity:	126/479 - (26%)
Similarity:	206/479 - (43%)	Gaps:	121/479 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RRVCVIGAGTAGLCALKNSLEAGLDAVAYERGTEIGGTWIFSEEMPKDEYDEVHSSMYEGLRTNL 73
            :||.::|||.:||.::|..||.||:...:||.:::||.|.|:|.:     :|..:|:|:.:.:|.
Mouse     3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHV-----EEGRASLYKSVVSNS 62

  Fly    74 PKEVMGYPDYSYPDDITESFITSNQVLEFLRSYAEHFKLKAHIKLQHEVIRVRPRLD-----DWE 133
            .:|:..|||:.:|:|. .:|:.::..||:|:.|:..|.|:..|....:|..:..|.|     .||
Mouse    63 SREMSCYPDFPFPEDY-PNFVPNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDFAVSGQWE 126

  Fly   134 VYVWDHSTDTCDPVYYDFVYVCNGHYTEPDLP--EVEGLDLFEGNKMHSHLYRKADKFKDARVLI 196
            |....:...  :...:|.|.||.|..|.|.||  ...|:..|:|...||..|:..|.|||.|||:
Mouse   127 VVTVTNGKQ--NSAIFDAVMVCTGFLTNPHLPLDSFPGILTFKGEYFHSRQYKHPDIFKDKRVLV 189

  Fly   197 IGAGPSGMDITNHVRLAAKQVFLS------------------------------HHLSTTPNTAF 231
            :|.|.||.||.......||:||||                              .:|..||..::
Mouse   190 VGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMIFMTRFQNMLRNLLPTPIVSW 254

  Fly   232 M---------------------------------------GNVTQKPDVKRFTKDGAVFTD-GST 256
            :                                       |.|..||.:|...::..||.: ...
Mouse   255 LISKKMNSWFNHVNYGVAPEDRTQLREPVLNDELPGRIITGKVFIKPSIKEVKENSVVFNNTPKE 319

  Fly   257 ESFDHVMFCTGYKYTFPCLSTDVGVQVIDNFVQPLWKHCI--NINHPTMAFVGL--PF-NVIPTH 316
            |..|.::|.|||.:.||.|  |..|..:::....|:|:..  ::..||:|.:||  |. :::||.
Mouse   320 EPIDIIVFATGYTFAFPFL--DESVVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMVPTG 382

  Fly   317 IFDMQVRFTLKFFTGQRKFPSREQMIADLEQEIGERWGCGVRNQKKAHQMG---------ERQFV 372
              :.|.|:.::...|....|....|:    :|:.||        ||....|         :..::
Mouse   383 --ETQARWVVQVLKGATTLPPPSVMM----EEVNER--------KKNKHSGFGLCYCKALQTDYI 433

  Fly   373 YYNE--LASIAGIENIKPVIHKLM 394
            .|.:  |.||    |.||.:..::
Mouse   434 TYIDDLLTSI----NAKPDLRAML 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fmo-2	NP_610217.1	NADB_Rossmann	12..214	CDD:304358	69/208 (33%)
Fmo1	NP_001317220.1	FMO-like	3..532	CDD:109787	126/479 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2072
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3710
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55225
OrthoDB	1	1.010	-	-		D308082at33208
OrthoFinder	1	1.000	-	-		FOG0000093
OrthoInspector	1	1.000	-	-		mtm8771
orthoMCL	1	0.900	-	-		OOG6_100150
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X69
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.780