Protein Alignment Bap170 and Arid2

DIOPT Version :10

• Sequence 1: NP_610216.1
• Gene: Bap170 / 35560
• FlyBaseID: FBgn0042085
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: NP_780460.3
• Gene: Arid2 / 77044
• MGIID: 1924294
• Length: 1828
• Species: Mus musculus
• Alignment Length: 2013
• Identity: 494/2013 - (24%)
• Similarity: 777/2013 - (38%)
• Gaps: 596/2013 - (29%)

  Fly    64 SPPEE------FWRDLQQFHERRGTPLTQPARISGKHVDLYKLYNEVTERGGFNKVTMRDEWDEV 122
            :||:|      |..:|:|||..||:|..:...:.||.:||:.||..||..|||.||:.:::|.|:
Mouse     8 APPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEI 72

  Fly   123 YSAMETLRERCVNGTASIKHIYRRYLDKYERLNFFGEDPDKMEALEAAIEIVEMGGGRSRSRFLA 187
            .......|. |.|...::|..|.|||:|||:::.||||.|::..
Mouse    73 VEEFNFPRS-CSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPP--------------------- 115

  Fly   188 GAGGGLGSIFGSAHSTLP--AVPMAYNQRQHSVNVERRRQYKMSTQLHRHSSYEKLLLSLLSPLP 250
                      |:....||  |:|.:||.:||||:...|:.|.:|...:..:.|.||:|||||.||
Mouse   116 ----------GNPKPQLPIGAIPSSYNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLP 170

  Fly   251 NEQDFAINVCTLMANEARHTLQLSECPKLLDVLLAHLGVYADF--TMRQLFQHSYTEVRHHSQLS 313
            ||.|||||||||::||::|.:||.:.||::.:|||:.||:.|.  :...:|...:.|......:.
Mouse   171 NEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSSVFGEEWREKTDRDFVK 235

  Fly   314 FWRDLLHDKPQVLELYTDEQ--------AWLDNGLISKEDGENSAARSELLAACDELHFLNLRRS 370
            ||:|::.|. :|.:|.:|..        .|:...|....                        |.
Mouse   236 FWKDIVDDN-EVRDLISDRNKAHEDTPGEWIWESLFHPP------------------------RK 275

  Fly   371 NGTDERMGQRVLQIVQLVRTLSFHQENHALLASNRTLWRYLVMGANVRWSNIHIQALETAGNLAQ 435
            .|.::..|||||||..::|.|||.:.|..|||:|||..|:|::.|:..:.::....|:|.||:|.
Mouse   276 LGINDIEGQRVLQIAVILRNLSFEESNVKLLAANRTCLRFLLLSAHSHFISLRQLGLDTLGNIAA 340

  Fly   436 QFELLDPTTDELSRNLLATLCEGIDSNDRAVIMSCLEILYKLCGREGNSQHINRCLGLDFYQRAM 500
            :. ||||.....:..:..|:.:.:.|.||.:.|..:|||..||..|.|...|...:..|.|:..:
Mouse   341 EL-LLDPVDFRTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREII 404

  Fly   501 LLLSLTDVMMIIFTLEAVYALSALGARPCSMLMQVRGLIDQLVTLITVEAQSYGTGGCILMRVVE 565
            ..|:|.||:::..|||.:|.|:.:|...|:.:.:|...||.||.|::::||.:|......::::|
Mouse   405 CHLTLPDVLLVTSTLEVLYMLTEMGDVACTKIAKVEKSIDVLVCLVSMDAQMFGPDALAAVKLIE 469

  Fly   566 VFPGNMAASLAQNMPAILAPGPTSLTTLPTSLQVAVKPPAVLPTPTPAQTQV-LPHGEQTPLVTA 629
             .|.:....|::                       ::|.|:    ...|||. :..|..:..|.|
Mouse   470 -HPSSSHQVLSE-----------------------IRPQAI----EQVQTQTHIASGPASRAVVA 506

  Fly   630 LPGLPMPSLPQVQLPVPSLPQVQLPPIAATVTLPSLPSASQSFTHEDEQYALAWLGATYERAGNG 694
            ....|.|.:.::                                 :.|::|..||.|.:|   ..
Mouse   507 QHAAPPPGIVEI---------------------------------DSEKFACQWLNAHFE---VN 535

  Fly   695 NDLRVEQAELYRIYLSHCQKAGKLSVVNHMQFPRLVRLIFNQSVGPVIVRHLDGIELPG---TYY 756
            .|..|.:||:|..|||.|.|..:..::....|.:.:|.:|....    |:.::.....|   .:.
Mouse   536 PDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHT----VKRVEDSTSSGQAHIHV 596

  Fly   757 VGIRMRAQPLAMQQ--------------------RPTPS----------------IVPVKKDTPI 785
            :|::.||.||.:|.                    .||||                ..||...:..
Mouse   597 IGVKRRALPLPIQMYYQQQPISTPVVRVDAVADLSPTPSPAGIPHGPQAAGNHFQRTPVTNQSSN 661

  Fly   786 LPKQPFSDPVQTEVASEESVSSAVTPPPSSSLIKSLLANK-VTERQQK-------------QKAQ 836
            |.....|.|||......::||..   ||:.|:......|. ||..|.|             |.:.
Mouse   662 LTATQMSFPVQGIHTVAQTVSRI---PPNPSVHTHQQQNSPVTVIQNKAPIPCEVVKATVIQNSV 723

  Fly   837 AQTPQPPALVATTASGTNAT--------QPIKVTSTAISAFVNNPLMQH---------------- 877
            .||..|.::....|...|:.        ||:.|        ||:..:.|
Mouse   724 PQTAVPVSISVGGAPAQNSVGQNHSAGPQPVTV--------VNSQTLLHHPSVMPQPSPLHTVVP 780

  Fly   878 ------TPVKVGQTTI------------------------------KPLH---PQMAIEKKPITD 903
                  |||.|.|.|:                              :|:|   .|.|...:| .|
Mouse   781 GQVPSGTPVTVIQQTVPQSRMFGRVQSIPACTSTVSQGQQLITTSPQPMHTSSQQTAAGSQP-QD 844

  Fly   904 S---APPPLAPLSGANVVT-------KDASGRTLIIASA-------------------------- 932
            :   |||.....|.:|:|:       :.|:|:.:.||..
Mouse   845 TVIIAPPQYVTTSASNIVSATSVQNFQVATGQVVTIAGVPSPQPSRVGFQNIAPKPLPSQQVSPS 909

  Fly   933 -----------AAKRKLTIDEEQNKR------------LALDAAASSSSSSSSGGKEEAQVTPSK 974
                       .|::.:.|..:..::            ||..||..:..:....|  :..:|||.
Mouse   910 VVQQPIQQPQQPAQQSVVIVSQPAQQGQAYAPAIHQIVLANPAALPAGQTVQLTG--QPNITPSS 972

  Fly   975 NAA-----NLYADLAASILEDEDMDDVPP-----LAKPSQEQSQQHPQ--------QAQQLQLIP 1021
            :.:     |.....|.|..........||     |:...|:|.|..|.        |.||.|.:.
Mouse   973 SPSPVPPTNNQVPTAMSSSSTLQSQGPPPTVSQMLSVKRQQQQQHSPAAPAQQVQVQVQQPQQVQ 1037

  Fly  1022 AKVQPTQRQLVFPGSNVVSPAPH-----SQLKLATTATIKTDQGLQTVPVILQPKTAMDSTPAPQ 1081
            .:|||.|     |.:.|..|||:     .||.|..... .|..|...:|....|.......|:||
Mouse  1038 VQVQPQQ-----PSAGVGQPAPNESSLIKQLLLPKRGP-STPGGKLILPAPQIPPPNNARAPSPQ 1096

  Fly  1082 TQYVLATNQ------QGQT----YLVAQQ---------------PTIPTSTQSAPPTLLVTQTP- 1120
            ..|.:|.||      ||||    .||.||               .|:|.|.....|..|::.:|
Mouse  1097 VVYQVANNQAAGFGVQGQTPAQQLLVGQQNVQLVQSAMPPAGGVQTVPISNLQILPGPLISNSPA 1161

  Fly  1121 --------QQQTKTII----------------ILQQPGGVSAANV---AGTQKMIMTTAQGQQVL 1158
                    .|.|.|::                .|..|.|:|.:..   ||.|  :.|...||.
Mouse  1162 TIFQGTSGNQVTITVVPNTSFATATVSQGNAAQLIAPAGLSMSGAQASAGLQ--VQTLPAGQS-- 1222

  Fly  1159 VTTTTAPQ-------LAQPRTSTPQQQIFIAPQRPVPAL------------GAGQMSPSLL---S 1201
             ..||||.       :.|......:.......:|.:..:            ..|..|.|.|   |
Mouse  1223 -ACTTAPLPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGTTNTSNGDTSESELQVGS 1286

  Fly  1202 QLN-------QIPATI--KLHQPQPQPQLVS--PQLAPQQRLVAAKPGA--SLPIPQLQQHQSII 1253
            .||       .:|.:.  ||.....|..|:|  |.|...:.   ..||.  |.|: .:|..:..:
Mouse  1287 LLNGRKYSDSSLPPSNSGKLQSETSQCSLISNGPSLELGEN---GAPGKQNSEPV-DMQDVKGDL 1347

  Fly  1254 QQHIISG-------------------------------PSTPTSTVGG----TVGGEKRQ----- 1278
            ::.:::|                               |..|..|.|.    |..|::.:
Mouse  1348 KKALVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPVEPQGTSGATQQDTAKGDQLERVSNG 1412

  Fly  1279 --VILGGIKETTLITQ--TSATPAPLQQSQLNSQTIITQSPTSTAIVGGVALQQQHHIRSVLDQQ 1339
              :.|||...|:.:.:  :.||| ||      |.|.:...|.::::...|..|:.    ||:...
Mouse  1413 PVLTLGGSPSTSSMQEAPSVATP-PL------SGTDLPNGPLASSLNSDVPQQRP----SVVVSP 1466

  Fly  1340 QQHHPSIIQ--QKITMPAISEATKPKIAPVPVS------------PTVTLLAKKPA--------P 1382
            ....| :||  |.|.:|    .:.|::.|..:|            .||    |:||        |
Mouse  1467 HSTAP-VIQGHQVIAVP----HSGPRVTPSALSSDARSTNGTAECKTV----KRPAEDNDRDTVP 1522

  Fly  1383 PQPAQV-------SSPKPSVTQAVVVTTSGTSDSTEGGKTVVLATSEAKPAESEVVAQTVVP--- 1437
            ..|.:|       |.|..:...|.:|.....:|.:...|..:.:.::.|........|:|.|
Mouse  1523 GIPNKVGVRIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAAQQKQQHPPTYMQSVAPQNT 1587

  Fly  1438 -----PAVVTTGPSSSSLVVSQSVYAASGPNANPTPSPMPVDANWLYICDWRNCPRKKFKSLNEL 1497
                 |||...|..|||   ..|..:||..:|:|...|     ...::|.|::| :|.|::.:::
Mouse  1588 PMPPSPAVQVQGQPSSS---QPSPVSASSQHADPVRKP-----GQNFMCLWQSC-KKWFQTPSQV 1643

  Fly  1498 QYHVCSVHCPDHLDSDADIY---CQWGSGPNFCDNRARKRYSLMTHLIDRHLTTENLRASVQRRL 1559
            .||..:.|      ...|:|   |.|..    |:...|:|:|.:|||.|:|.:.:.|.|.:::
Mouse  1644 FYHAATEH------GGKDVYPGQCLWEG----CEPFQRQRFSFITHLQDKHCSKDALLAGLKQ-- 1696

  Fly  1560 ATGIHNVAPTQAPVTIVRNEGHAQRLAGGATGSPSGPASAVPVVGSAAMQAMNRHTTDYTNAKEL 1624
                      ..|..:...:...::...|.|||......|:....|||:.|:.|.:.:.. .::.
Mouse  1697 ----------DEPGQVANQKSSTKQPTVGGTGSAPRAQKAIASHPSAALMALRRGSRNLV-FRDF 1750

  Fly  1625 MDENEGPVTKSIRLTAALIIRNLVTYSATAKRSLKRYESRLANVAFSNVEASGVLSHIMYELS 1687
            .||.|||:||.||||||||::|:..||...:|.|||:|:.|:.:|.||:|||..|:..:|||:
Mouse  1751 TDEKEGPITKHIRLTAALILKNIGKYSECGRRLLKRHENNLSVLAISNMEASSTLAKCLYELN 1813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bap170	NP_610216.1	ARID	69..152	CDD:460187	32/82 (39%)
		RFX_DNA_binding	677..763	CDD:460512	22/88 (25%)
		Atrophin-1	1059..>1429	CDD:460830	110/530 (21%)
Arid2	NP_780460.3	ARID_ARID2	15..102	CDD:350630	33/87 (38%)
		LXXLL. /evidence=ECO:0000250|UniProtKB:Q68CP9	313..317		1/3 (33%)
		RFX_DNA_binding	521..603	CDD:460512	22/88 (25%)
		SP1-4_N	676..1152	CDD:425404	102/495 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	824..843		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	962..1028		14/67 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1245..1339		20/97 (21%)
		PTZ00395	1278..>1575	CDD:185594	66/320 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1360..1462		20/112 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1483..1503		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1566..1618		15/54 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1697..1726		5/28 (18%)