DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trap1 and hsp90b1

DIOPT Version :9

Sequence 1:	NP_001260726.1	Gene:	Trap1 / 35559	FlyBaseID:	FBgn0026761	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001039228.1	Gene:	hsp90b1 / 734089	XenbaseID:	XB-GENE-494760	Length:	803	Species:	Xenopus tropicalis

Alignment Length:	751	Identity:	245/751 - (32%)
Similarity:	375/751 - (49%)	Gaps:	111/751 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VRAMGVLGQACRLGRCAQVLRQSHRSAPAAFNITIGSQHSPGALSLRRYSTETK--QASG----- 60
            :|....:|..|.|...|.|..:......|.....||.............|.|.:  |..|
Frog     1 MRKFWAIGLCCILLAFASVQAEDEVEVDATVEDDIGKSRDGSRTDDEVVSREEEAIQIDGLNAAQ 65

  Fly    61 -----SVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGK 120
                 ...:|..||||..:::.::..|||.:.|:|:|||||||||||:|.|..||:  .||....
Frog    66 IKELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLT--DENALAA 128

  Fly   121 DRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNI 185
            :..|.|:|..||....|.|.|||||||||:||.||||||:||:.:||.::...|:  ..:::|.:
Frog   129 NEELTIKIKCDKEKNMLHITDTGIGMTKEDLVKNLGTIAKSGTSEFLSKLTDAQE--DGQSTSEL 191

  Fly   186 IGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVP---DVELGTRIVLHLKT 247
            ||||||||||:|:||::|.|.::.  .|.....|.:| |..:.:.:.|   .:..||.|.|.||.
Frog   192 IGQFGVGFYSAFLVADRVIVTSKH--NNDTQHIWESD-SNEFFVNDDPRGDTLGRGTTITLVLKE 253

  Fly   248 DCREYADEERIKAVIKKYSNFVGSPIL------------LNGKQA-------------------- 280
            :..:|.:.|.||.:::|||.|:..||.            |:.::|
Frog   254 EATDYLELETIKNLVRKYSQFINFPIYVWSSKTETVEEPLDEEEAKEKDEETDEEAAVEEEDEEK 318

  Fly   281 -----------------NEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPLSIH 328
                             |:|||:|....:.|.::::..||:..|...|.|...:|:.|:..::..
Frog   319 KPKTKKVEKTVWDWELMNDIKPIWQRPSKEIEEDEYKAFYKSFSKEADDPMAYIHFTAEGEVTFK 383

  Fly   329 ALLYFPEGKP-GLF-EMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLSRE 391
            ::|:.|...| ||| |.....:..:.|:.|:|.|......::||:|.||||||||:|:|||:|||
Frog   384 SILFIPTTAPRGLFDEYGSKKSDFIKLFVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRE 448

  Fly   392 LLQNSSLIRKLSSVISTRVIRFLQERSKKQPEE--YEAFYRDYGLFLKEGIVTSSDASEKEEIAK 454
            .||.    .||..||..:::|...:..||..|:  .:.|::::|..:|.|::  .|.|.:..:||
Frog   449 TLQQ----HKLLKVIRKKLVRKTLDMIKKIAEDKYTDKFWKEFGTNIKLGVI--EDHSNRTRLAK 507

  Fly   455 LLRFESS--KSETASGRMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCY 517
            ||||:||  ||||.    |||:|...:..:|..||::|..:|...||||:.|.|.|:...|||..
Frog   508 LLRFQSSNNKSETT----SLEQYVERMKEKQDKIYFIAGASRKEVESSPFVERLLKKGYEVLFLI 568

  Fly   518 EPYDELVLMQLGKFKSKKLVSVEKE-----MREESKETTATTDFGEGSLLRSELDTLIPWLEEE- 576
            ||.||..:..|.:|..|:..:|.||     ..|:|||..        ..|..|.:.|:.|::|:
Frog   569 EPVDEYCIQALPEFDGKRFQNVAKEGLKFDENEKSKEAR--------EALEKEYEPLLTWMKEKA 625

  Fly   577 LRGQVIKVKATTRLDTHPCVITVEEMAAA---RHFIRTQSHQVPEQ---NRFALLQPELEINPKH 635
            |:.|:.|...:.||...||.:...:...:   ...::.|::|..:.   |.::..:...||||:|
Frog   626 LKDQIEKAVVSQRLTQSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYSGQKKTFEINPRH 690

  Fly   636 PIIKKL---NKLRESDKDLAQLIAKQLFANAMVGAG 668
            |:||::   .|..|.||.:|.| |..||..|.:.:|
Frog   691 PLIKEMLQRVKENEDDKTVADL-AVVLFETATLRSG 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trap1	NP_001260726.1	PRK05218	65..689	CDD:235366	232/677 (34%)
		HATPase_c	91..246	CDD:280651	71/157 (45%)
		HSP90	251..688	CDD:278607	149/488 (31%)
hsp90b1	NP_001039228.1	HATPase_Hsp90-like	83..275	CDD:340404	85/198 (43%)
hsp90b1	NP_001039228.1	HSP90	257..754	CDD:365929	149/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D924636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920