DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trap1 and hsp90b1

DIOPT Version :9

Sequence 1:	NP_001260726.1	Gene:	Trap1 / 35559	FlyBaseID:	FBgn0026761	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_937853.1	Gene:	hsp90b1 / 386590	ZFINID:	ZDB-GENE-031002-1	Length:	793	Species:	Danio rerio

Alignment Length:	781	Identity:	252/781 - (32%)
Similarity:	392/781 - (50%)	Gaps:	117/781 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VRAMGVLGQACRLGRCAQVLRQSHRSAPAAFNITIGS------------QHSPGALSLRRYSTET 55
            :|.:.::|..|.|...|.|...............:|.            |....|:.|...:|..
Zfish     1 MRRLWIIGLLCALLAFASVKADDDVDIDGTVEEDLGKSRDGSRTDDEVVQREEEAIQLDGLNTSQ 65

  Fly    56 KQASGSVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGK 120
            .:......:||.||||..:::.::..|||.:.|:|:|||||||||||:|.|..||: ..:.|||.
Zfish    66 LKEIRDKAEKHAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLLSLT-NEDALAGN 129

  Fly   121 DRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNI 185
            :. |.|:|.:||....|.|.||||||||||||.||||||:||:.:||.:|...|.  .|:::|.:
Zfish   130 EE-LTIKIKSDKEKNMLHITDTGIGMTKEELVKNLGTIAKSGTSEFLNKMTEVQD--DSQSTSEL 191

  Fly   186 IGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVP---DVELGTRIVLHLKT 247
            ||||||||||:|:||:||.|.::.  .|.....|.:| |..:.:.|.|   .:..||.|.|.:|.
Zfish   192 IGQFGVGFYSAFLVADKVIVTSKH--NNDTQHMWESD-SNQFSVIEDPRGDTLGRGTTITLVMKE 253

  Fly   248 DCREYADEERIKAVIKKYSNFVGSPILL------------------------------------- 275
            :..:|.:.|.||.::||||.|:..||.:
Zfish   254 EASDYLELETIKNLVKKYSQFINFPIYVWSSKTETVEEPIEDEAEAEKEEATEDEAEVEEEEEDK 318

  Fly   276 -------------NGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPLSI 327
                         :.:..|:|||:|....:.:.::::..||:..|...|.|...:|:.|:..::.
Zfish   319 DKPKTKKVEKTVWDWELMNDIKPIWQRPAKEVEEDEYTAFYKTFSRDTDEPLSHIHFTAEGEVTF 383

  Fly   328 HALLYFPEGKP-GLF-EMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLSR 390
            .::|:.|...| ||| |.....|..:.|:.|:|.|......::||:|.|:||||||:|:|||:||
Zfish   384 KSILFVPASAPRGLFDEYGTKKNDFIKLFVRRVFITDDFHDMMPKYLNFIKGVVDSDDLPLNVSR 448

  Fly   391 ELLQNSSLIRKLSSVISTRVIRFLQERSKKQPEEY--EAFYRDYGLFLKEGIVTSSDASEKEEIA 453
            |.||.    .||..||..:::|...:..||..||.  :.|::::|..:|.|::  .|.|.:..:|
Zfish   449 ETLQQ----HKLLKVIRKKLVRKTLDMIKKIAEEQYNDKFWKEFGTNIKLGVI--EDHSNRTRLA 507

  Fly   454 KLLRFESSKSETASGRMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCYE 518
            |||||::|.|:|...  |||:|...:..:|..||::|..:|..|||||:.|.|.|:...|::..|
Zfish   508 KLLRFQTSHSDTVLS--SLEQYVERMKEKQDKIYFMAGTSRKEAESSPFVEKLLKKGYEVVYLTE 570

  Fly   519 PYDELVLMQLGKFKSKKLVSVEKE-----MREESKETTATTDFGEGSLLRSELDTLIPWLEEE-L 577
            |.||..:..|.:|..|:..:|.||     ..:::||        :...|..|.:.|..|:::: |
Zfish   571 PVDEYCIQALPEFDGKRFQNVAKEGVKFDESDKAKE--------KREALEKEFEPLTTWMKDKAL 627

  Fly   578 RGQVIKVKATTRLDTHPCVITVEEMAAA---RHFIRTQSHQVPEQ---NRFALLQPELEINPKHP 636
            :.|:.|...:.||...||.:...:...:   ...::.|::|..:.   |.:|..:..||||||||
Zfish   628 KEQIEKAVLSQRLTNSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTLEINPKHP 692

  Fly   637 IIKK-LNKLRE--SDKDLAQLIAKQLFANAMVGAGL-AED--------PRMLLTNMNTLLSRALE 689
            :||: |.::.|  .||..|.| |..||..|.:.:|. .:|        .|||..:||..|...:|
Zfish   693 LIKEMLRRVNEDAEDKTAADL-AVVLFETATLRSGYQLQDTKAYGERIERMLRLSMNVDLDAQVE 756

  Fly   690 K 690
            :
Zfish   757 E 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trap1	NP_001260726.1	PRK05218	65..689	CDD:235366	240/704 (34%)
		HATPase_c	91..246	CDD:280651	77/157 (49%)
		HSP90	251..688	CDD:278607	151/514 (29%)
hsp90b1	NP_937853.1	PRK05218	74..746	CDD:235366	237/695 (34%)
		HATPase_c	98..216	CDD:238030	69/123 (56%)
		HSP90	257..755	CDD:278607	151/514 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D924636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820