Protein Alignment Trap1 and Hsp90b1

DIOPT Version :10

• Sequence 1: NP_477439.2
• Gene: Trap1 / 35559
• FlyBaseID: FBgn0026761
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001012197.2
• Gene: Hsp90b1 / 362862
• RGDID: 1310482
• Length: 804
• Species: Rattus norvegicus
• Alignment Length: 776
• Identity: 236/776 - (30%)
• Similarity: 385/776 - (49%)
• Gaps: 125/776 - (16%)

  Fly     3 VRAMGVLGQACRL---------------GRCAQVLRQSHRSAPAAFNITIGSQHSPGALSLRRYS 52
            :|.:.|||..|.|               |...:.|.:|...:.....:.   |....|:.|...:
  Rat     1 MRVLWVLGLCCVLLTFGFVRADDEVDVDGTVEEDLGKSREGSRTDDEVV---QREEEAIQLDGLN 62

  Fly    53 TETKQASGSVVDKHEFQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENL 117
            ....:......:|..||||..:::.::..|||.:.|:|:|||||||||||:|.|..||:  .||.
  Rat    63 ASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLT--DENA 125

  Fly   118 AGKDRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEAS 182
            ...:..|.::|..|:....|.:.|||:|||:||||.||||||:||:.:||.:|...|:  ..:::
  Rat   126 LAGNEELTVKIKCDREKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQE--DGQST 188

  Fly   183 SNIIGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPD-----VELGTRIV 242
            |.:||||||||||:|:||:||.|.::.  .|.....|.:|.:   |...:.|     :..||.|.
  Rat   189 SELIGQFGVGFYSAFLVADKVIVTSKH--NNDTQHIWESDSN---EFSVIADPRGNTLGRGTTIT 248

  Fly   243 LHLKTDCREYADEERIKAVIKKYSNFVGSPILL-------------------------------- 275
            |.||.:..:|.:.:.||.:::|||.|:..||.:
  Rat   249 LVLKEEASDYLELDTIKNLVRKYSQFINFPIYVWSSKTETVEEPLEEDETAQEEKEEADDEAAVE 313

  Fly   276 ------------------NGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNAD 322
                              :.:..|:|||:|....:.:.::::..||:..|...|.|...:|:.|:
  Rat   314 EEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAE 378

  Fly   323 VPLSIHALLYFPEGKP-GLF-EMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIP 385
            ..::..::|:.|...| ||| |.....:..:.||.|:|.|......::||:|.||||||||:|:|
  Rat   379 GEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLP 443

  Fly   386 LNLSRELLQNSSLIRKLSSVISTRVIRFLQERSKK-QPEEY-EAFYRDYGLFLKEGIVTSSDASE 448
            ||:|||.||.    .||..||..:::|...:..|| ..|:| :.|::::|..:|.|::  .|.|.
  Rat   444 LNVSRETLQQ----HKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVI--EDHSN 502

  Fly   449 KEEIAKLLRFESSKSETASGRMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELV 513
            :..:||||||:||...|  ...||::|...:..:|..||::|..:|..|||||:.|.|.|:...|
  Rat   503 RTRLAKLLRFQSSHHST--DITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEV 565

  Fly   514 LFCYEPYDELVLMQLGKFKSKKLVSVEKE-----MREESKETTATTDFGEGSLLRSELDTLIPWL 573
            ::..||.||..:..|.:|..|:..:|.||     ..|:|||:...|:        .|.:.|:.|:
  Rat   566 IYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKSKESREATE--------KEFEPLLNWM 622

  Fly   574 EEE-LRGQVIKVKATTRLDTHPCVITVEEMAAA---RHFIRTQSHQVPEQ---NRFALLQPELEI 631
            ::: |:.::.|...:.||...||.:...:...:   ...::.|::|..:.   |.:|..:...||
  Rat   623 KDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEI 687

  Fly   632 NPKHPIIK-KLNKLRESDKDLAQL-IAKQLFANAMVGAG-LAED--------PRMLLTNMN 681
            ||:||:|: .|.:::|.:.|...: :|..||..|.:.:| |..|        .|||..::|
  Rat   688 NPRHPLIRDMLRRVKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLN 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trap1	NP_477439.2	HtpG	65..689	CDD:440095	224/699 (32%)
Hsp90b1	NP_001012197.2	SRT pseudosubstrate motif. /evidence=ECO:0000250|UniProtKB:P14625	42..44		0/1 (0%)
		HATPase_Hsp90-like	83..275	CDD:340404	82/200 (41%)
		HSP90	257..755	CDD:459703	143/508 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..323		0/34 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	749..804		236/776 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	801..804