Protein Alignment Trap1 and HSP90AA1

DIOPT Version :10

• Sequence 1: NP_477439.2
• Gene: Trap1 / 35559
• FlyBaseID: FBgn0026761
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001017963.2
• Gene: HSP90AA1 / 3320
• HGNCID: 5253
• Length: 854
• Species: Homo sapiens
• Alignment Length: 756
• Identity: 237/756 - (31%)
• Similarity: 372/756 - (49%)
• Gaps: 137/756 - (18%)

  Fly    31 AAFNIT--IGSQHSPGA-----------LSLRRYSTETKQASGSVVDKHE-----FQAETRQLLD 77
            :||.:|  :..:.|.||           :.||....|..|.....:::.|     ||||..||:.
Human    89 SAFPVTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLMS 153

  Fly    78 IVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGKDRPLEIRITTDKPLMQLIIQDT 142
            ::..:.||:.|:|:||||||:||||:|.||.||:...:..:||:  |.|.:..:|....|.|.||
Human   154 LIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKE--LHINLIPNKQDRTLTIVDT 216

  Fly   143 GIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNIIGQFGVGFYSSFIVANKVEVFT 207
            ||||||.:|::||||||:||:|.|:|.:   |.|    |..::||||||||||:::||.||.|.|
Human   217 GIGMTKADLINNLGTIAKSGTKAFMEAL---QAG----ADISMIGQFGVGFYSAYLVAEKVTVIT 274

  Fly   208 RAAVPNAPGLRWSTDGSGTYEIEEVPDVELGTRIVLHLKTDCREYADEERIKAVIKKYSNFVGSP 272
            :...........|..||.|...:....:..||:::||||.|..||.:|.|||.::||:|.|:|.|
Human   275 KHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYP 339

  Fly   273 ILL-------------------------------------------------------------- 275
            |.|
Human   340 ITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKE 404

  Fly   276 ---NGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPLSIHALLYFPEGK 337
               :.::.|:.||:|...|..|:.|::.:||:.::|.::......|::.:..|...|||:.|...
Human   405 KYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRA 469

  Fly   338 P-GLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLSRELLQNSSLIRK 401
            | .||| :|.....:.||.|:|.|....|.|:|::|.|::|||||||:|||:|||:||.|.:::.
Human   470 PFDLFE-NRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKV 533

  Fly   402 LSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGIVTSSDASEKEEIAKLLRFESSKSETA 466
            :...:..:.:....|.::.: |.|:.||..:...:|.||  ..|:..::::::|||:.:|    |
Human   534 IRKNLVKKCLELFTELAEDK-ENYKKFYEQFSKNIKLGI--HEDSQNRKKLSELLRYYTS----A 591

  Fly   467 SG--RMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCYEPYDELVLMQLG 529
            ||  .:||::|...:...|::|||:....:....:|.:.|.|:|....|::..||.||..:.||.
Human   592 SGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLK 656

  Fly   530 KFKSKKLVSVEKE-------MREESKETTATTDFGEGSLLRSELDTLIPWLEEELRGQVIKVKAT 587
            :|:.|.||||.||       ..|:.|:....|.|          :.|...:::.|..:|.||..:
Human   657 EFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKF----------ENLCKIMKDILEKKVEKVVVS 711

  Fly   588 TRLDTHPCVITVEEMAAARHFIRTQSHQVPEQNR---FALLQPELEINPKHPIIKKLNKLRESD- 648
            .||.|.||.|.........:..|....|....|.   :...:..|||||.|.||:.|.:..|:|
Human   712 NRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADK 776

  Fly   649 -----KDLAQLIAKQLFANAMVGAGLA-EDPRMLLTNMNTL 683
                 |||..|    |:..|::.:|.: |||:   |:.|.:
Human   777 NDKSVKDLVIL----LYETALLSSGFSLEDPQ---THANRI 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trap1	NP_477439.2	HtpG	65..689	CDD:440095	227/709 (32%)
HSP90AA1	NP_001017963.2	HSP90	140..854	CDD:481033	226/705 (32%)