DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trap1 and hsp90ab1

DIOPT Version :9

Sequence 1:	NP_001260726.1	Gene:	Trap1 / 35559	FlyBaseID:	FBgn0026761	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_571385.2	Gene:	hsp90ab1 / 30573	ZFINID:	ZDB-GENE-990415-95	Length:	725	Species:	Danio rerio

Alignment Length:	689	Identity:	226/689 - (32%)
Similarity:	356/689 - (51%)	Gaps:	98/689 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 FQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGKDRPLEIRITTDK 132
            ||||..||:.::..:.||:.|:|:|||:|||||||:|.||.||:...:..:|||..::|.....:
Zfish    16 FQAEIAQLMSLIINTFYSNKEIFLRELVSNASDALDKIRYESLTDPTKLDSGKDLKIDIIPNVQE 80

  Fly   133 PLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNIIGQFGVGFYSSF 197
            ..:.||  ||||||||.:|::||||||:||:|.|:|.:   |.|    |..::||||||||||::
Zfish    81 RTLTLI--DTGIGMTKADLINNLGTIAKSGTKAFMEAL---QAG----ADISMIGQFGVGFYSAY 136

  Fly   198 IVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPDVELGTRIVLHLKTDCREYADEERIKAVI 262
            :||.||.|.|:...........|..||.|.:::....:..||:::||||.|..||.:|:|:|.|:
Zfish   137 LVAEKVTVITKHNDDEQYAWESSAGGSFTVKVDHGEPIGRGTKVILHLKEDQTEYIEEKRVKEVV 201

  Fly   263 KKYSNFVGSPILL---------------------------------------------------- 275
            ||:|.|:|.||.|
Zfish   202 KKHSQFIGYPITLYVEKERDKEISDDEAEEEKAEKEEKEEEGEDKPKIEDVGSDDEEDTKDKDKK 266

  Fly   276 ----------NGKQANEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPLSIHAL 330
                      :.::.|:.||:|...|..||.|::.:||:.::|.::......|::.:..|...||
Zfish   267 KKKKIKEKYIDQEELNKTKPIWTRNPDDISNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRAL 331

  Fly   331 LYFPEGKP-GLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLSRELLQ 394
            |:.|...| .|||..:..| .:.||.|:|.|....|.|:|::|.|::|||||||:|||:|||:||
Zfish   332 LFIPRRAPFDLFENKKKKN-NIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQ 395

  Fly   395 NSSLIRKLSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGIVTSSDASEKEEIAKLLRFE 459
            .|.:::.:...|..:.:....|.::.: :.|:.||..:...||.||  ..|:..::::::|||::
Zfish   396 QSKILKVIRKNIVKKCLELFAELAEDK-DNYKKFYDAFSKNLKLGI--HEDSQNRKKLSELLRYQ 457

  Fly   460 SSKSETASGRMSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCYEPYDELV 524
            ||:|  .....||.||.:.:...|::|||:...::.....|.:.|.:.||...||:..||.||..
Zfish   458 SSQS--GDEMTSLTEYVSRMKENQKSIYYITGESKDQVAHSAFVERVCKRGFEVLYMTEPIDEYC 520

  Fly   525 LMQLGKFKSKKLVSVEKEMREESKETTATTDFGEGSLLRSELDTLIPWLEEELRGQVIKVKATTR 589
            :.||..|..|.||||.||..|..::........|.   :::.:.|...::|.|..:|.||..:.|
Zfish   521 VQQLKDFDGKSLVSVTKEGLELPEDEDEKKKMEED---KAKFENLCKLMKEILDKKVEKVTVSNR 582

  Fly   590 LDTHPCVITVEEMAAARHFIRTQSHQVPEQNR---FALLQPELEINPKHPIIKKLNKLRESD--- 648
            |.:.||.|.........:..|....|....|.   :.:.:..|||||.|||::.|.:..|:|
Zfish   583 LVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIMETLRQKAEADKND 647

  Fly   649 ---KDLAQLIAKQLFANAMVGAGLA-EDPRMLLTNMNTL 683
               |||..|    ||..|::.:|.: :||:   |:.|.:
Zfish   648 KAVKDLVIL----LFETALLSSGFSLDDPQ---THSNRI 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trap1	NP_001260726.1	PRK05218	65..689	CDD:235366	226/689 (33%)
		HATPase_c	91..246	CDD:280651	68/154 (44%)
		HSP90	251..688	CDD:278607	145/506 (29%)
hsp90ab1	NP_571385.2	PTZ00272	13..725	CDD:240341	226/689 (33%)
		HATPase_c	34..185	CDD:214643	70/159 (44%)
		HSP90	190..715	CDD:278607	145/506 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..269		0/48 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..725
		TPR repeat-binding	721..725
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D924636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820